Oral dissolving film: present and future aspects
Over the past few decades, tendency toward innovative drug delivery systems has almightily increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Orally fast dissolving film is the kind of drug delivery system which when placed in the oral cavity, disintegrate or dissolve within a few seconds without the intake of water. Oral fast dissolving film is relatively new dosage form in which thin film is prepared using hydrophilic polymers, which rapidly disintegrate or dissolves on tongue or in the buccal cavity It is an alternative platform for molecules that undergoes high first pass metabolism. The method of preparation for oral dissolving film. Solvent casting, Semisolid casting, Hot melt extrusion, Solid dispersion extrusion, Rolling The current evaluation gives an account of different formulations methods of preparation and quality control of the fast dissolving oral thin film.
Keyword: First pass metabolism, Tensile strength, Fast Dissolving Oral Film etc.
2. . Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Chandra RM, Fast dissolving tablet: an overview. J Chem Pharm Res 2009; 1:163–77
3. Flash release oral films of metoclopramide hydrochloride for pediatric use: formulation and in-vitro evaluation. Raju S, Reddy PS, Kumar VA, Deepthi A, Reddy KS, Reddy PVM. J Chem Pharm Res 2011; 3(4):636–46.
4. Routes of drug administration. Verma P, Thakur AS, Deshmukh K, Jha AK, Verma S. Int J Pharm StudiesRes 2010; 1(1):54–9.
5. Formulation of a novel Tianeptine sodium orodispersible film. Setouhy DA, Malak NS. AAPS Pharm Sci Tech 2010; 11(3):1018–25.
6. Fast disintegrating tablets: an overview of formulation, technology, and evaluation Puttalingaiah L, Kunchu K, Tamizh M. Res J Pharm Biol Chem Sci 2011; 2(2)
7. Avinash KG, Fast Dissolving Dosage Forms, IJPSI, 2013; 2:14-17.
8.Shweta K, Mayank B, Recent trends in the development of oral dissolving film, Int J PharmTech Res, 2012; 4:725-733.
9. Swamy NGN, Shiva KS, Formulation and evaluation of fast dissolving oral films of palanosetron hydrochloride using HPMC-E5, International journal of pharmaceutical and chemical sciences, 2014; 3:145-150.
10. Sri rekha M, Shaheda SK, Mahathi K, Praveen P, PrathimaB, Seetha Devi A, Formulation and evaluation of fastdissolving buccal film containing isradipine soliddispersion, Am J PharmTech Res, 2015; 5:94–107.
11. Dahiya M, Saha S, Shahiwala A, A review on mouthdissolving films, Curr Drug Deliv, 2009; 6:469-76.
12. Sandeep S, Arun N, Monika HK, Fast Dissolving Films (FDF):Innovative drug delivery system, Pharmacologyonline, 2011; 2:919-928.
13. Naziya K, Raghavendra R NG, Mahipal R, Overview on fast dissolving oral films, Int J Chem Pharm Sci, 2013; 41(9):661-680.
14.Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications Zhang, H.; Zhang, J.; Streisand, J.B. Clin. Pharmacokinet, 20
15. Naziya K, Raghavendra R NG, Mahipal R, Overview on fastdissolving oral films, Int J Chem Pharm Sci, 2013; 1:63-75.
16. Mashru RC, Sutariya BC, Parikh PP, Development and evaluation of fast dissolving films of salbutamol sulphate. Drug Dev Ind Pharm. 31; 2005:25-34.
17. Gohel MC, Sharma R, Soniwala MM. Development of taste masked film of Valdecoxib for oral use. Indian Journal of Pharmaceutical Sciences. 2007; 69:318-320.
18. Koland M, Charyulu N, Fast dissolving sublingual films of ondansetron hydrochloride: Effect of addivites on in vitro drug release and mucousal permeation. Journal of Young Pharm. 2010; 2:216-221.
19. Singh S, Gangwar S, Formulation and evaluation of rapidly disintegrating film of levocetrizine hydrochloride. Der Pharmacia Lettre. 2010; 2:434-439.
20. Kulkarni N, Kumar LD, Sorg A, Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent. U.S. Patent 2003, 206942.
21. Juliano C, Cossu M, Preparation, In Vitro Characterization and Preliminary In Vivo Evaluation of Buccal Polymeric Films Containing Chlorhexidine. AAPS PharmSciTech. 2008; 9:1153-1159.
22. Fast Dissolving Oral Films Technology: A Recent Trend For An Innovative Oral Drug Delivery System Deepak Sharma, Daljit Kaur, Shivani Verma, Davinder Singh, Mandeep Singh, Gurmeet Singh, Rajeev Garg, International Journal of Drug Delivery 2015; 7:60-75.
23. Fast dissolving drug delivery system: a review, Arunachalam, A., M. Karthikeyan, S. Ashutoshkumar and K. Kishore,. Journal of Global Trends in Pharmaceutical Sciences, 2010; 1(1):92-110.
24. Upendra CG, Sunil S K, Yuvraj GJ, Praveen DC, Investigation of different polymers, plasticizers and superdisintegrating agents alone and in combination for use in the formulation of fast dissolving oral films, Int J PharmTech Res, 2013; 5:1465-1472.
25. Vishwakarma DK, Tripathi AK, Yogesh P, Maddheshiya B, Review article on mouth dissolving film, Journal of Global Pharma Technology, 2011; 3:1-8.
26. Gavaskar B, Vijayakumar S, Sharma G Rao YM, Overview on fast dissolving films, International Journal of Pharmacy and Pharmaceutical Sciences, 2010; 2:9-33.
27. Kalyan S, Bansal M, Recent trends in the development of oral dissolving films, International Journal of Pharm Tech Research, 42012; 4:725-733.
28. Parul S, Anoop K, Pankaj S, Sharad V, Fast disintegrating oral films: a recent trend of drug delivery, Int J Drug Dev & Res, 4, 2012; 4:80-94.
29. Fast Dissolving Oral Films: A Review Naga Sowjanya Juluru International Journal Of Advances In Pharmacy, Biology And Chemistry, 2003; 2(1).
30. Handbook of Pharmaceutical Excipients. Wale. A and Weller. P J., 2nd edition, 1994; 24(27):352,448.
31. An Overview of Fast Dissolving Oral Films Chonkar Ankita D., Bhagawati S. T., Udupa N.* Asian J. Pharm. Tech. 2015; 5(3):129-137.
32. Development of ebiana, a natural, non-caloric sweetener, Prakash.G.E, DuBois.J.F, Clos.K.L, Wilkens and Fosdick. L.E., Food Chem. Toxicol. 2008; 46:S75-S82.
33. Development of innovative orally fast disintegrating film dosage forms: a review. B.P. Panda, N. S. Dey and M.E.B Rao. International Journal of Pharmaceutical Sciences and Nanotechnology. 2012; 5(2).
34. Oral strip technology: Overview and future potential. Dixit RP, Puthli SP, Journal of Controlled Release.2009; 139:94–107.
35. Technical Brief 2010. Vol 3 Particle Sciences Drug Development Service.
36. Hypromellose, Ethylcellulose and Polyethylene oxide used in hot melt extrusion. Coppens, K.A., M.J. Hall, S.A. Mitchell and M.D. Read, 2005. Pharmaceutical Technol., pp: 1-6.
37. A Short Review on “A Novel Approach in Oral Fast Dissolving Drug Delivery System and Their Patents” M.D. Nehal Siddiqui, Garima Garg and Pramod Kumar Sharma. Advances in Biological Research 2011; 5(6):291-303.
38. Nehal S, Garima G, Pramod K S, A short review on “a novel approach in oral fast dissolving drug delivery system and their patents”, Advan Biol Res, 2011; 5:291-303.
39. Pandya K, Patel KR, Patel MR, Patel NM, Fast dissolving films: a novel approach to oral drug delivery, Asian Journal of Pharmaceutical Science & Technology, 2013; 3:25-31.
40 . Naga Sowjanya Juluru. Fast dissolving oral films: a review. IJAPBC, 2013; 2(1):108-112.
41. Repka MA, Prodduthuri S, Stodghill S.P. Production andcharacterization of hot-melt extruded films containingclotrimazole. Drug Dev Ind Pharm, 2003; 29:757-765.
42. Pallavi C, Patil, Shrivastava SK, Vaidehi S, Ashwini P, Oral fast dissolving drug delivery system: a modern approach for patient compliance, International Journal of Drug Regulatory Affairs, 2014; 2:49–60.
43. Panda BP, Dey NS, Rao MEB, Development of innovative orally fast disintegrating film dosage forms: a review, Int J Pharm Sci Nanotech, 2012; 5:1666-1674
44. Gowri R, Narayanan N, Revathy S, Prabhavathy P, PreethyMG, Rekha G. Melt in mouth films-an effective alternative drug delivery system, 2014, 2666-2680.
45. Rajini B, Pravin P, Sushil K, Sandeep A, Orally dissolvingstrips – a new approach to oral drug delivery system, Int J Pharm Investing, 2013; 3:67-68.
46. Han Jung H, Floros John, Casting antimicrobial packaging films and measuring their physical properties and antimicrobial activity. Journal of Plastic Film and Sheeting, 1997; 13:287-297
47. Jutaporn Chana-Thaworn, Suphitchaya C, Thawien W,Properties and antimicrobial activity of edible film incorporated with kaim wood extract, LWT – Food Science and Technology. 2011; 44:284-292.
48. D. Archana J, Vijaya V, Dr. Uma MR, Formulation and evaluation of oral thin films containing saxagliptin, IJJIPSR, 2014; 2:2669-2690
49. Ankita K, Dr. Pramod KS, Dr. Nayyar P, Fast dissolving oral film: a novel and innovative drug delivery system, IJPSR, 2014; 5:92-95.
50. Sumedha B, Mayank B, Gopal G, Formulation and evaluation of fast dissolving film of an antihypertensive drug, IJPCBS, 2013; 3:1097-1108.
51. Pardeep KJ, Sachin S, Rajni B, Fast dissolving oral films: novel way for oral drug delivery, International Journal of Universal Pharmacy and Bio Sciences, 2014; 3:6-29.
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