Antibiotic evaluation of odontogenic microbiological spectrum of orofacial infection

  • Neha Vishnoi Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India
  • Sapna Singh Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India
  • Ram Singh Bishnoi School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, Madhya Pradesh, India.
  • M K Gupta Oral Maxillofacial Surgeon, Nagpur, Maharashtra, India

Abstract

The present study aimed towards the development of active delivery system for management of hypertension. The Orodispersible tablets (ODTs) containing Telmisartan was developed in order to accomplish enhanced solubility leading to better bioavailability profile. Different ratios, of Telmisartan and PEG 6000 i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were selected for the formulation of ODT system. A batch process was adopted for the preparation of solid dispersion with each combination of drug and polymer and the finally compressed as tablets by direct compression technique. For the preformulation perspective materials were scrutinized on the basis of solubility profile, drug content, Fourier Transform Infrared (FTIR) spectroscopy and Differential scanning calorimetry (DSC). The drug polymer ratio 1:4 was selected for further compression process. The prepared batches of ODTs were characterized for micromeritic study, thickness, hardness, weight variation, wetting time, disintegration time, drug content and in vitro drug release profile. The evaluation data for all batches was satisfactory out of them formulation TF3 containing 6% kyron T-314 showed the best results with a value of 29.3 sec and 24.1 sec for wetting and disintegration, respectively. This formulation showed superior drug release of 99.93% over a period of 30 minutes.


Keywords: Telmisartan, PEG 6000, Angioten receptor-II antagonist, Solid dispersion, Kyron T-314

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Author Biographies

Neha Vishnoi, Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India

Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India

Sapna Singh, Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India

Peoples Dental Academy, People’s University, Bhopal, Madhya Pradesh, India

Ram Singh Bishnoi, School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, Madhya Pradesh, India.

School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, Madhya Pradesh, India.

M K Gupta, Oral Maxillofacial Surgeon, Nagpur, Maharashtra, India

Oral Maxillofacial Surgeon, Nagpur, Maharashtra, India

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How to Cite
Vishnoi, N., Singh, S., Bishnoi, R. S., & Gupta, M. K. (2018). Antibiotic evaluation of odontogenic microbiological spectrum of orofacial infection. Journal of Drug Delivery and Therapeutics, 8(6), 179-182. https://doi.org/10.22270/jddt.v8i6.2038