Development of mosquito repellant gel formulations from various natural volatile oils: comparative study with the marketed formulation odomos®
DEET based mosquito repellents were found to be comparatively harmful to the person suffering from urea cycle disorders such as ornithine transcarbamylase (OTD) deficiency and, are therefore, contraindicated in individuals. These situations lead to the budding necessity of natural mosquito repellents which will have inexpensive, effectual, non-toxic, environment-friendly, and biodegradable attributes. Inspired from the upcoming global need, a carbopol 940 based mosquito repellant gel formulation was prepared from the essential oils of Cymbopogon nardus, Murraya Koenigii, Cymbopogon citratus, Tridax procumbens, Eucalyptus globules, and Azadirachta indica, and further evaluating them for their appearance, pH, viscosity, spreadability, extrudability, swelling index, and accelerated studies. The mosquito repellent potential was evaluated and simultaneously compared with the positive control (Odomos®). In several developing nations, where the majority of the people do not have access to mosquito net, high-cost mosquito repellant creams, and miscellaneous physical methods, this gel formulation may be an effective, inexpensive, and easily accessible way to prevent mosquito-borne diseases, like malaria, dengue, etc. in the lower sections of the society.
Keywords: Mosquito, Repellent, Malaria, Gel, Formulation, DEET.
2. Mahapatra DK, Bharti SK, Asati V. Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives. Eur J Med Chem 2015; 101:496-524.
3. Guillet P, Alnwick D, Cham MK, Neira M, Zaim M, Heymann D, Mukelabai K. Long-lasting treated mosquito nets: a breakthrough in malaria prevention. Bull World Health Org, 2001; 79.
4. Girard MP, Reed ZH, Friede M, Kieny MP. A review of human vaccine research and development: malaria. Vaccine, 2007; 25(9):1567-1580.
5. Roberts DR, Alecrim WD, Hshieh P, Grieco JP, Bangs M, Andre RG, Chareonviriphap T. A probability model of vector behavior: effects of DDT repellency, irritancy, and toxicity in malaria control. J Vect Ecol, 2000; 25(1):48-61.
6. Rowland M, Freeman T, Downey G, Hadi A, Saeed M. DEET mosquito repellent sold through social marketing provides personal protection against malaria in an area of all‐night mosquito biting and partial coverage of insecticide‐treated nets: a case–control study of effectiveness. Trop Med Int Health, 2004; 9(3):343-50.
7. Gordon N. Ornithine transcarbamylase deficiency: a urea cycle defect. Eur J Paediatr Neurol, 2003; 7(3):115-21.
8. Heick HM, Peterson RG, Dalpe-Scott M, Qureshi IA. Insect repellent, N, N-diethyl-m-toluamide, effect on ammonia metabolism. Pediatrics, 1988; 82(3):373-376.
9. Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999; 86(6):985-90.
10. Ranasinghe MS, Arambewela L, Samarasinghe S. Development of Herbal Mosquito Repellent Formulations. Int J Pharm Sci Res, 2016; 7(9):3643-3648.
11. Jadhav VD, Talele Swati G, Bakliwal Akshada A, Chaudhari GN. Formulation and Evaluation of Herbal Gel Containing Leaf Extract of Tridax Procumbens. J Pharm Biosci, 2015; 3:65-72.
12. Gupta R, Gupta GD. Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia oblique Topical Gel on Animal Model. Pharmacogn J, 2017; 9(6):s93-s98.
13. Mahajan UN, Mahapatra DK, Mahajan NM, Kazi FS, Baghel N. Exploring the role of Mahua oil as potent emulsifier in cream formulations. Int J Herb Med, 2017; 5(3):93-7.
14. Aiyalu R, Govindarjan A, Ramasamy A. Formulation and evaluation of topical herbal gel for the treatment of arthritis in animal model. Braz J Pharm Sci, 2016; 52(3):493-507.
15. Mahajan NM, Pardeshi A, Mahapatra DK, Darode A, Dumore NG. Hypromellose and Carbomer induce bioadhesion of Acyclovir tablet to vaginal mucosa. Indo Am J Pharm Res, 2017; 7(12):1108-1118.
16. Godbole MD, Mahapatra DK, Khode PD, Fabrication and Characterization of Edible Jelly Formulation of Stevioside: A Nutraceutical or OTC Aid for the Diabetic Patients. Inventi Rapid: Nutraceut, 2017; 2:1-9.
17. Mahajan UN, Mahapatra DK, Mahajan NM, Kazi FS, Baghel N. Mahua oil containing suppository base exhibited higher drug release as compared to cocoa butter base. J Nat Prod Plant Resour, 2017; 7(3):8-14.
18. Patil SC, Gadade DD, Rathi PB. Design, Development and Evaluation of Herbal Gel for Treatment of Psoriasis. J Innovat Pharm Biol Sci, 2015; 2(1):72-87.
19. Umaredkar AA, Dangre PV, Mahapatra DK, Dhabarde DM (2018) Fabrication of chitosan-alginate polyelectrolyte complexed hydrogel for controlled release of cilnidipine: a statistical design approach. Mater Technol, 27:1-1.
20. Formulation and Evaluation of Gel Contains the Combination of Ethanol Extract Basil leaves (Ocimum sanctum L.) and Soursop Leaves (Annona muricata L.) as a Mosquito Repellent. Int J Pharm Pharm Res, 2016; 7(2):10-18.
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