Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout)

  • Harsh Sehgal PG Scholar, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India
  • Bhavna Singh Prof. and HOD, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India
  • Sanandan Thapliyal Associate Prof., Department of Kaya Chikitsa, Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

Abstract

Andrographis paniculata (Burm.f.) Wall. Ex. Nees (A. Paniculata), i.e. Kalmegha is a medicinal plant traditionally used for various diseases such as fever, diarrhea, worm infestation, hepatic and skin diseases. Modern studies have also explicitly revealed that A. Paniculata has a wide range of pharmacological effects such as anti-inflammatory, anti-hyperglycemic, anti-diarrhoeal, anti-viral, anti-malarial, hepato-protective, anti-cancer, anti-human immunodeficiency virus (HIV), and also work as an immune stimulator. On the other hand, Gout (Vatarakta) is one common metabolic disorder which affects over 1% of the world’s adult population.


Objective: To assess the clinical efficacy of A.Paniculata in Gouty Arthritis.


Study Design: A clinical research, prospective in style, wherein a hypothesis, based on the previous studies on the various effects of A. Paniculata, was made; to assess its efficacy in treating Gout.


Methodology: Randomly selected patients (n = 31) were administered powder of A. Paniculata, 2 gms thrice daily with water, for 45 days with a follow-up in every 15 days for one month. Assessment of the treatment was based on before treatment (BT) and after treatment (AT) effects of A. Paniculata on the parameters namely; subjective, i.e. the symptoms of Gout and objective, i.e. the levels of Serum Uric Acid.


Results: In subjective parameters, Wilcoxon non-parametric test was used. The outcome shows that except the symptom i.e. Pallor (shwetata), in all other symptoms of Gout, p value was either < 0.05 or < 0.01, which is considered to be significant to highly significant. In objective parameter, Z test was used, in which the outcome of p value was < 0.01, which indicates that the effect of A.Paniculata on Serum Uric Acid is highly significant.


Keywords: Kalmegha, Andrographis paniculata, Gout, Vatarakta, Serum Uric Acid, Clinical Studies

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Author Biographies

Harsh Sehgal, PG Scholar, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

PG Scholar, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

Bhavna Singh, Prof. and HOD, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

Prof. and HOD, PG Department of Dravya Guna Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

Sanandan Thapliyal, Associate Prof., Department of Kaya Chikitsa, Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

Associate Prof., Department of Kaya Chikitsa, Uttaranchal Ayurvedic College, Dehradun, Uttarakhand, India

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How to Cite
Sehgal, H., Singh, B., & Thapliyal, S. (2018). Role of Kalmegha (Andrographis paniculata (Burm.F.) Wall. Ex Nees) in treating Vatarakta (Gout). Journal of Drug Delivery and Therapeutics, 8(6), 98-101. https://doi.org/10.22270/jddt.v8i6.2024