Formulation development and optimization of fast dissolving film containing carvedilol nanocrystals for improved bioavailability

  • Anju Sharma Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India
  • P Sriganesan Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India

Abstract

In this work, fast dissolving films (FDF) were prepared using nanocrystal formulations in order to optimise dissolution properties of lipophilic, poorly soluble drug Cavedilol. Drug nanocrystals are crystals with a size in the nanometer range, meaning that they are nanoparticles with a crystalline character. Carvedilol nanosuspensions were prepared using a high-pressure homogenizer, and then encapsulated in to films by solvent casting method using polymers such as maltodextrin and PVA in different concentrations. Propylene glycol used as a plasticizer. This study aimed to develop and evaluate the formulation of FDF containing Carvedilol nanocrystals for enhanced bioavailability and better compliance. The formulation of FDF was optimized by Box-Behnken Design (BBD) (design expert 11.03).In this design, 13 formulas were performed. One of the formula were suggested by design expert desirability = 1.


Keywords: Carvedilol, Nanocrystal, FDF, Box-bhenken optimization, in-vitro drug dissolution study,

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Author Biographies

Anju Sharma, Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India

Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India

P Sriganesan, Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India

Department of Pharmaceutical Sciences, RIMSR, CPAS, Kottayam , Kerala – 686009, India

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How to Cite
Sharma, A., & Sriganesan, P. (2018). Formulation development and optimization of fast dissolving film containing carvedilol nanocrystals for improved bioavailability. Journal of Drug Delivery and Therapeutics, 8(6), 74-81. https://doi.org/10.22270/jddt.v8i6.2017