Enhanced dissolution and solubility of Epalrestat with β-Cyclodextrin ternary complex using Arginine

  • Sneha Jagtap Annasaheb Dange College of B Pharmacy, Ashta, Sangli - 416301 Maharashtra, India.
  • Magdum Chandrakant Rajarambapu College of Pharmacy, Kasegaon, Sangli -415404 Maharashtra, India.

Abstract

The objective of present is work to achieve improvement in solubility and dissolution using Epalrestat with β-cyclodextrin ternary complex with addition of L-arginine. Kneading method with and without incorporation of L-arginine was used to obtain the solid systems (binary and ternary complex) of Epalrestat with β-cyclodextrin and characterized for DSC, PXRD, SEM. Phase solubility, saturation solubility, dissolution and stability studies were carried out. The effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase solubility according to Higuchi and Connors. Phase solubility studies showed AL (linear) type of solubility curve in presence of L-arginine, the complexation efficiency and association constant of β-cyclodextrin towards Epalrestat were promoted by L-arginine signifying its use as a ternary component. Dissolution rate of Epalrestat and solubility were significantly improved by complexation with β-cyclodextrin as compared to Epalrestat alone. Ternary complex incorporated with L-arginine proved better than binary complex. Hence, L-arginine could be exploited as a ternary component to improve the solubility of Epalrestat via β-cyclodextrin complexation.


Keywords: Epalrestat, solubility enhancement, inclusion complexes, β-cyclodextrin, L-arginine.

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Author Biographies

Sneha Jagtap, Annasaheb Dange College of B Pharmacy, Ashta, Sangli - 416301 Maharashtra, India.

Annasaheb Dange College of B Pharmacy, Ashta, Sangli - 416301 Maharashtra, India.

Magdum Chandrakant, Rajarambapu College of Pharmacy, Kasegaon, Sangli -415404 Maharashtra, India.

Rajarambapu College of Pharmacy, Kasegaon, Sangli -415404 Maharashtra, India.

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How to Cite
Jagtap, S., & Chandrakant, M. (2018). Enhanced dissolution and solubility of Epalrestat with β-Cyclodextrin ternary complex using Arginine. Journal of Drug Delivery and Therapeutics, 8(6), 62-67. https://doi.org/10.22270/jddt.v8i6.2014