DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE

  • NILESH M MAHAJAN Dr.
  • Kalyanee Wanaskar Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India
  • Yogesh Bhutada Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India
  • Raju Thenge Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India
  • Vaibhav Adhao Dr. Rajendra Gode College of Pharmacy, Malkapur-443101, India

Abstract

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15,  it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%.  Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study


Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC

Downloads

Download data is not yet available.

Author Biographies

Kalyanee Wanaskar, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Yogesh Bhutada, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Raju Thenge, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Dadasaheb Balpande College of Pharmacy, Besa, Nagpur-440034, India

Vaibhav Adhao, Dr. Rajendra Gode College of Pharmacy, Malkapur-443101, India

Dr. Rajendra Gode College of Pharmacy, Malkapur-443101, India

References

1. Martins O. Emeje Olobayo O. Kunle1 S. Ofoefule Effect of the molecular size of carboxymethylcellulose and some polymers on the sustained release of theophylline from a hydrophilic matrix. Acta Pharm.2006; 56:325-335.
2. Amaral MH, Sousa Lobo JM, Ferreira DC. Naproxen availability from variable dose and wet sustained released tablets, Drug Dev. Ind. Pharmacy.2001; 13:123-133.
3. Kumar, M.N.V.R. and N. Kumar. Polymeric controlled drug delivery systems: perspectives issues and opportunities. Drug Dev. Ind. Pharm. 2001; 27:1-30.
4. Dixit N Sustain release drug delivery system. Indian J Res. Pharmacy and Biotech 2013; 1(3):305 – 310.
5. Rother KI . "Diabetes treatment— bridging the divide", The New England Journal of Medicine. 2007; 356(15
6. Dey HB, Kumar S, Kumar D, Formulation, Characterization and invitro evaluation of Floating microspheres of Nateglinide. Int. J Pharma & Bio Sciences; 2011, P147.
7. C. V. S. Subramanyam, Textbook of Physical Pharmaceutics, Vallabh Prakashan 9thedition 2008, pp181-225.
8. Lieberman HA ,Lachman L, Pharmaceutical dosage form; Tablet 2nd edition, Marcel and Dekker ,New York
9. Barde L N, Wadekar A B, Aher S R, Thenge R R, Formulation and Evaluation of Extended Release Tablet of Metoprolol Succinate. World J Pharm Sci., 2016, 5(6):1302-1316..
10. Patel KB, Vyas JR, Upadhayay UM,” Formulation and Evaluation of Sustained Release Matrix Tablets of Nateglinide”. Journal of Drug Delivery & Therapeutics. 2015; 5(5):19-25. https://doi.org/10.22270/jddt.v5i5.1130
11. Venkateshvarlu K, Formulation and Evaluation of Sustained Release Matrix Tablets of Repaglinide. Bangladesh Pharma Journal, 2016; 19(1):92-99.
Statistics
44 Views | 60 Downloads
How to Cite
MAHAJAN, N., Wanaskar, K., Bhutada, Y., Thenge, R., & Adhao, V. (2018). DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE. Journal of Drug Delivery and Therapeutics, 8(5-s), 235-239. https://doi.org/10.22270/jddt.v8i5-s.2012
Section
Research