PREPARATION AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES OF INSULIN FOR NASAL DELIVERY

  • Subhendu Sekhar Mishra Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india
  • Ashish Sharma Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india

Abstract

The aim of this study was to prepare and evaluate nanoparticles containing insulin in different polymer ratio by ionotropic gelation method. The average particle size was found to be 130.4±3.4 -155.5±6.4nm. SEM indicates that nanoparticles have shown smooth and spherical shape. The zeta potential of optimized formulation was 35.5 mv which indicates moderate stability with no agglomeration. The average drug content was found to be 130.4±3.4 -155.5±6.4nm. The in vitro drug release data was analyzed using zero order, first order, Higuchi, and Korsmeyer-Peppas models. It was observed the best fit model for nanoparticles was higuchi model. The developed formulation in situ polymeric gel is designed in such a way that the gel will load insulin in higher concentration and it will also contain penetration enhancer which will enhance the absorption of release drug from gel to systemic circulation.


Keywords: Insulin, Nanoparticle, invitro drug release study.

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Author Biographies

Subhendu Sekhar Mishra, Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india

Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india

Ashish Sharma, Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india

Institute of Pharmacy, Nims University, Jaipur, Rajasthan, india

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How to Cite
Mishra, S. S., & Sharma, A. (2018). PREPARATION AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES OF INSULIN FOR NASAL DELIVERY. Journal of Drug Delivery and Therapeutics, 8(5-s), 400-406. https://doi.org/10.22270/jddt.v8i5-s.2002
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Research