PREPARATION OF CONTROLLED RELEASE METFORMIN HYDROCHLORIDE LOADED CHITOSAN MICROSPHERES AND EVALAUTION OF FORMULATION PARAMETERS

  • Mrs Kalpna Shivalik College of Pharmacy, Nangal, Punjab, India
  • Druv Dev Shivalik College of Pharmacy, Nangal, Punjab, India
  • Mohammad Shahnaz Shivalik College of Pharmacy, Nangal, Punjab, India
  • Jyoti Parkash Shivalik College of Pharmacy, Nangal, Punjab, India
  • DN Prasad Shivalik College of Pharmacy, Nangal, Punjab, India

Abstract

In this work an attempt was made for the preparation and evaluation of controlled release chitosan microspheres using anti-diabetes drug Metformin hydrochloride. The microspheres were prepared by Ionotropic gelation method using chitosan as polymer and Sodium Tripolyphosphate (TPP) as crosslinking agent. The compatibility of drug and polymer is analyzed by using FTIR and DSC method. There was no interaction detected by FTIR and DSC study. Further the prepared microspheres were evaluated for particle size, drug entrapment efficiency, surface morphology, drug content, drug loading and in vitro drug release. Amongst all the formulation batch 7 shows the best release when compared to other batch. SEM (Scanning electron microscopy) revealed that microspheres were spherical and porous. Finally it was concluded that Metformin hydrochloride loaded chitosan – TPP microspheres have been found suitable for controlled release formulation due to its bioavailability and biodegradability and thus lead to improved patient compliance.


Keywords: Microspheres, Metformin hydrochloride, Ionotropic gelation method, chitosan.

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Author Biographies

Mrs Kalpna, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

Druv Dev, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

Mohammad Shahnaz, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

Jyoti Parkash, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

DN Prasad, Shivalik College of Pharmacy, Nangal, Punjab, India

Shivalik College of Pharmacy, Nangal, Punjab, India

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How to Cite
Kalpna, M., Dev, D., Shahnaz, M., Parkash, J., & Prasad, D. (2018). PREPARATION OF CONTROLLED RELEASE METFORMIN HYDROCHLORIDE LOADED CHITOSAN MICROSPHERES AND EVALAUTION OF FORMULATION PARAMETERS. Journal of Drug Delivery and Therapeutics, 8(5-s), 378-387. https://doi.org/10.22270/jddt.v8i5-s.1995
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Research