FORMULATION AND EVALUATION OF MATRIX TRANSDERMAL PATCHES OF GLIBENCLAMIDE

  • Syed Ata Ur Rahman College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Pachama, Sehore (M.P.) 466001, India
  • Neeraj Sharma School of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, 462044, India

Abstract

The present study deals with the formulation and evaluation of transdermal patches of Glibenclamide towards enhance its permeation through the skin and maintain the plasma level concentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and iso-propylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Among the formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observed for the formulations F12 and F4 i.e. 80.012 ± 2.012 % and 98.365±3.012% respectively. The mechanism of drug release was found to be Non-Fickian diffusion controlled. FT-IR studies revealed the integrity of the drug in the formulations.


Keywords: Transdermal Patches, Glibenclamide, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.

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Author Biographies

Syed Ata Ur Rahman, College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Pachama, Sehore (M.P.) 466001, India

College of Pharmacy, Sri Satya Sai University of Technology & Medical Sciences, Pachama, Sehore (M.P.) 466001, India

Neeraj Sharma, School of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, 462044, India

School of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal, 462044, India

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How to Cite
Rahman, S. A. U., & Sharma, N. (2018). FORMULATION AND EVALUATION OF MATRIX TRANSDERMAL PATCHES OF GLIBENCLAMIDE. Journal of Drug Delivery and Therapeutics, 8(5-s), 366-371. https://doi.org/10.22270/jddt.v8i5-s.1993
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Research