FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF MEBENDAZOLE AS A GASTRO RETENTIVE DOSAGE FORM

  • Lokesh Parmar Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India
  • Mansi Gupta Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India
  • Geeta Parkhe Scan Research Laboratories, Bhopal (M.P.), India
DOI https://doi.org/10.22270/jddt.v8i5-s.1980

Abstract

The present study involves preparation and evaluation of floating microspheres using Mebendazole (MBZ) as a model drug for improving the drug bioavailability by prolongation of gastric retention time.  Ethyl cellulose, hydroxyl propyl methyl cellulose microspheres loaded with mebendazole were prepared by solvent diffusion evaporation method. The microspheres had smooth surfaces, with free-flowing and good-packing properties. The yield of the microspheres was up to 85.65±0.14% and ethyl cellulose microspheres entrapped the maximum amount of the drug. Scanning electron microscopy confirmed their hollow structures with sizes in the range 215.1 to 251.80 nm. The prepared microspheres exhibited prolonged drug release and Percentage buoyancy was found to70.25±0.15. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, swelling studies. The formulations were subjected to Stability studies and In-vitro release and Release kinetics data was subjected to different dissolution models.


Keywords: solvent diffusion evaporation method, Mebendazole, Ethyl cellulose, Hydroxyl propyl methyl cellulose

Downloads

Download data is not yet available.

Author Biographies

Lokesh Parmar, Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India

Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India

Mansi Gupta, Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India

Technocrats Institute of Technology-Pharmacy, Bhopal (M.P.), India

Geeta Parkhe, Scan Research Laboratories, Bhopal (M.P.), India

Scan Research Laboratories, Bhopal (M.P.), India

References

1. Garg S.; Sharma, S. Gastroretentive drug delivery systems. In: Business Briefing. Pharma Tech., p.160-166, 2003.
2. Singh B. M.; Kim K. H. Floating drug delivery systems: an approach to controlled drug delivery via gastric retention. J. Control. Release, 2000; 63:235-259.
3. DESAI S.; BOLTON S. A floating controlled-release drug delivery system: in vitro-in vivo evaluation. Pharm. Res., 1993; 10:1321-1325
4. Whitehead L.; Fell J.T.; Collett J.H.; Sharma H.L.; Smith, A.M. Floating dosage form: an in vivo study demonstrating prolonged gastric retention. J. Control. Release, 1998; 55:3-12.
5. Iannuccelli V.; Coppi G.; Bernabei M.T.; Cameroni R. Air compartment multiple-unit system for prolonged gastric residence. Part I. Formulation study. Int. J. Pharm., 1998; 174:47-54.
6. Kawashima, Y.; Niwa, T.; Takeuchi, H.; Hino, T.; Itoh, Y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J. Pharm. Sci., 1992; 81:135-140.
7. http://en.wikipedia.org/wiki/Mebendazole
8. Mastrelli F., Cirri M., Mennini N., Mura P. Development of enteric coated calcium pectnate microspheres intended fof colonic drug delivery”. Eur J Pharm and Biopharm. 69: 508-518
9. Tanwar Y S, Naruka P S, Ojha G R. Development and evaluation of floating microspheres of verapamil hydrochloride. Brazilian Journal of Pharmaceutical Sciences, 2007; 43(4):529-534.
10. Sinha V. R.; Agrawal M. K.; Kumria R. Influence of formulation and excipient variables on the pellet properties prepared by extrusion spheronization. Curr. Drug Delivery, 2005; 2:1-8.
11. The United States Pharmacopoeia XXIV, United States Pharmacopoeial Convention, Rockville, 2000; 1941-1943.
12. Patil H.S., Patil M.P., Tekade B.W. et al.: Arch. Pharm. Sci. Res. 2009; 1:194.
13. Deepaa M.K., Karthikeyanb M.: Iranian J. Pharm. Sci. 2009; 5:69.
Statistics
44 Views | 52 Downloads
How to Cite
Parmar, L., Gupta, M., & Parkhe, G. (2018). FORMULATION, CHARACTERIZATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERES OF MEBENDAZOLE AS A GASTRO RETENTIVE DOSAGE FORM. Journal of Drug Delivery and Therapeutics, 8(5-s), 311-314. https://doi.org/10.22270/jddt.v8i5-s.1980
Issue
Vol 8 No 5-s (2018)
Section
Research
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

 

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

 

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

 

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Â