• Priyanka Singh Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India
  • Shailendra K Lariya Radharaman College of pharmacy, Bhopal, India


Acyclovir [9-(2-hydroxyethoxymethyl) guanine] is an acyclic nucleoside analogue of guanosine that is a potent and selective antiviral agent. It has a relatively short plasma half-life (3 hr). When orally administered, it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Acyclovir and produced sustained drug delivery. In these 14 batches of acyclovir microspheres was prepared with using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were evaluated for different parameters i.e % Drug yield, % drug entrapment, shape, surface morphology, particles size, polydispersity index, zeta potential and in-vitro drug release for 48 hrs in phosphate buffer 7.4. The best batch was performed stability studies for 6 months. The research concluded that Acyclovir microspheres could be an alternative for conventional dosage form and other phytochemical in herbs.

Keywords: Acyclovir, Microspheres, Kondagogu gum, Polydispersity index, in-vitro drug release


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Author Biographies

Priyanka Singh, Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India

Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India

Shailendra K Lariya, Radharaman College of pharmacy, Bhopal, India

Radharaman College of pharmacy, Bhopal, India


1. Choi BY, Park HJ, Hwang SJ. Preparation of alginate beads for floating drug delivery system effects of CO2 gas forming agents, International Journal of Pharmaceutics, 2002; 239:81-91.
2. Tekade BW, Jadhao UT, Thakare VM, Yogita A, Chaudhari, Vaishali DP, Chaudhari C S. Design and In-vitro evaluation of ethyl cellulose based floating microspheres containing antidiabetic drug, Asian Journal of Biomedical and Pharmaceutical Sciences, 2013; 3 (23):33-37.
3. Malaekeh-Nikouei B, Tabassi SAS, Jaafari MR, Davies NM. Preparation and characterization of PLGA microspheres loaded by cyclosporine-cyclodextrin complex, Iranian Journal of Pharmaceutical Sciences, 2005; 1(4):195-201.
4. Karal-Yılmaz O, Serhatl M, Baysal K, Baysal BM. Preparation and in vitro characterization of vascular endothelial growth factor (VEGF)-loaded poly(D,L-lactic-co-glycolic acid) microspheres using a double emulsion/solvent evaporation technique, Journal of Microencapsulation, 2011; 28(1):46-54.
5. El-Bagory IM, Hosny EA, Al-Suwayeh SA, Mahrous GM, Al-Jenoobi FI. Effects of sphere size, polymer to drug ratio and plasticizer concentration on the release of theophylline from ethylcellulose microspheres, Saudi Pharmaceutical Journal, 2007; 15(3-4):213-217.
6. Liu H, Pan W, Ke P, Dong Y, Ji L. Preparation and evaluation of a novel gastric mucoadhesive sustained-release acyclovir microsphere, Drug Development and Industrial Pharmacy, 2010): 36(9):1098-1105.
7. Basu SK, Adhiyaman R. Preparation and characterization of nitrendipine loaded eudragit rl 100 microspheres prepared by an emulsion-solvent evaporation method, Tropical Journal of Pharmceutical Research, 2008; 7 (3):1033-1041.
8. Lakshmana PS, Shirwaikar AA, Shirwaikar A, Kumar A. Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac, ARS Pharmaceutica, 2009;50 (2):51-62.
9. Kataria S, Middha A, Sandhu P, Bilandi A, Kapoor B. Microspheres- a review, International Journal of Research in Pharmacy and Chemistry, 2011; 1(4):1184-1198.
10. Verbeken D, Dierchx S, Dewettinck K. Exudate gums: occurrence, production and applications, Applied Microbiology and Biotechnology, 2003; 63:10-21.
11. Phillips GO, Williams PA. Tree exudates gums: natural and versatile food additives and ingredients, Food Ingredients Anal Int, 2001; 23:26-28.
12. FDA (Food, Drug Administration). Sterculia (karaya) gum, Federal Register, 1974; 39:34209–34211.
13. FAO (Food Agriculture Organization). Compendium of Food Additive Specifications; FAO: Rome, Italy, 1991; 11:821- 823.
14. Janaki B, Sashidhar RB. Physico-chemical analysis of gum kondagogu (Cochlospermum gossypium): A potential food additive, Food Chemistry, 1998; 61:231-236.
15. Janaki B, Sashidhar RB. Sub-chronic (90-day) toxicity study in rats fed gum kondagogu (Cochlospermum gossypium), Food Chemistry Toxicology, 2000; 38:523-534.
16. Vinod VTP, Sashidhar RB, Suresh KI, Rama Rao B, Vijaya Saradhi UVR, Prabhakar Rao T. Morphological, physico-chemical and structural characterization of gum kondagogu (Cochlospermum gossypium): a tree gum from India, Food Hydrocolloids, 2008; 22 (5):899-915.
17. Hayden FG. Antiviral agents. In: Hardman JG, Limbird LE, editors. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th ed., McGraw-Hill, USA, 1996; 1195.
18. Celum C, et al. Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial, Lancet, 2008; 371(9630):2109-2119.
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How to Cite
Singh P, Lariya SK. FORMULATION DEVELOPMENT OF ACYCLOVIR MICROSPHERE USING NOVEL NATURAL POLYMER. JDDT [Internet]. 1Oct.2018 [cited 22Oct.2021];8(5-s):271-6. Available from: