FORMULATION DEVELOPMENT OF ACYCLOVIR MICROSPHERE USING NOVEL NATURAL POLYMER

  • Priyanka Singh Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India
  • Shailendra K Lariya Radharaman College of pharmacy, Bhopal, India

Abstract

Acyclovir [9-(2-hydroxyethoxymethyl) guanine] is an acyclic nucleoside analogue of guanosine that is a potent and selective antiviral agent. It has a relatively short plasma half-life (3 hr). When orally administered, it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Acyclovir and produced sustained drug delivery. In these 14 batches of acyclovir microspheres was prepared with using natural polymer Kondagogu gum and other ingredients by solvent evaporation technique. The prepared microspheres were evaluated for different parameters i.e % Drug yield, % drug entrapment, shape, surface morphology, particles size, polydispersity index, zeta potential and in-vitro drug release for 48 hrs in phosphate buffer 7.4. The best batch was performed stability studies for 6 months. The research concluded that Acyclovir microspheres could be an alternative for conventional dosage form and other phytochemical in herbs.


Keywords: Acyclovir, Microspheres, Kondagogu gum, Polydispersity index, in-vitro drug release

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Author Biographies

Priyanka Singh, Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India

Department of pharmaceutics, Pacific academy of higher education & research University, Jaipur, India

Shailendra K Lariya, Radharaman College of pharmacy, Bhopal, India

Radharaman College of pharmacy, Bhopal, India

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How to Cite
Singh, P., & Lariya, S. K. (2018). FORMULATION DEVELOPMENT OF ACYCLOVIR MICROSPHERE USING NOVEL NATURAL POLYMER. Journal of Drug Delivery and Therapeutics, 8(5-s), 271-276. https://doi.org/10.22270/jddt.v8i5-s.1971
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Research