TITRIMETRIC ASSAY OF SOME ANTIHISTAMINE DRUGS WITH PYRIDINIUM FLUORO CHROMATE (PFC) REAGENT

  • Ajay Kumar Pandey Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)
  • Dharmendra Dwivedi Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)

Abstract

In the present paper, simple, convenient accurate, precise and cost effective  titrimetric (Visual volumetric) method has been reported for the estimation of some antihistamine drugs e.g. Cyproheptadine hydrochloride (CPH), Fexofenadine hydrochloride (FFH), Promethazine hydrochloride (PMH) and Pheniramine maleate (PM) in pure form and in their pharmaceutical preparations such as Ciplactin (Tab), Allegra (Tab), Phenergan (Tab and Inj) and Avil (Tab and Inj) with Pyridinium fluoro chromate (PFC) reagent. The principle of this method is based on the fact, that each pharmaceutical drug consists of certain organic functional group which on oxidation  by a known excess of potassium iodate in sulphuric acid medium followed by iodometric titration in presence of reagent Pyridinium fluoro chromate (PFC) establishes stoichiometric relationship between drug molecule and an oxidising reagent Pyridinium fluoro chromate (PFC).Different results obtained for each drug during experiment, has been validated by different statistical parameters such as percentage error, standard deviation (SD) and coefficient of variation (CV).Results obtained from these statistical parameters proves the accuracy and precision of adopted method.

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Author Biographies

Ajay Kumar Pandey, Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)

Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)

Dharmendra Dwivedi, Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)

Department of Chemistry, Pt. S.N.S. Govt. P.G. (Auto) College, Shahdol, M. P. (India)

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How to Cite
Pandey, A., & Dwivedi, D. (2018). TITRIMETRIC ASSAY OF SOME ANTIHISTAMINE DRUGS WITH PYRIDINIUM FLUORO CHROMATE (PFC) REAGENT. Journal of Drug Delivery and Therapeutics, 8(5), 407-410. https://doi.org/10.22270/jddt.v8i5.1947