• Jaspreet Kaur Saini Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India
  • Sandeep Kumar Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India


With the advancement in modern pharmaceutical technologies, Nanotechnology is the one of the most establish technology which is used to improve the therapeutic index and to overcome the formulation challenges of poorly water-soluble compounds. Nanocrystals, in nano range, is the interesting approach for poorly soluble drugs. Due to the small size, increased surface area enhanced the dissolution rate and solubility of drug. In this paper, current technologies and methods in nanocrystal preparation, stabilization, pharmaceutical applications and limitations of nanocrystal are reviewed.

Keywords: Nanocrystal, limitations, stabilization, preparation, applications


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Author Biographies

Jaspreet Kaur Saini, Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India

Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India

Sandeep Kumar, Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India

Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela (Roper), Punjab, India


1. Peltonen L, Hirvonen J, Drug nanocrystals – Versatile option for formulation of poorly soluble materials, International Journal of Pharmaceutics, 2018; 537:73-83.
2. Sinha B, Müller Rainer H., Möschwitzer JP., Bottom-up approaches for preparing drug nanocrystals: formulations and factors affecting particle size, International Journal of Pharmaceutics, 2013;13: 35-5.
3. Chen H, Khemtong C, Yang X, Chang X, Gao J, Nanonization strategies for poorly water-soluble drugs, Drug Discovery Today,2011;662:1-7 .
4. Sawant SV, Kadam VJ, Jadhav KR., and Sankpal SV, Drug Nanocrystals: Novel Technique For Delivery Of Poorly Soluble Drugs, International Journal Of Science Innovations And Discoveries, 2011; 1(3):1-5.
5. Patel V, Sharma Om P and Mehta T, Nanocrystal: a novel approach to overcome skin barriers for improved topical drug delivery, Expert Opinion on Drug Delivery, 2018.
6. Ahuja Bhupesh K., Jena Sunil K., Paidi Sharan K., Bagri S. and Suresh S., Formulation, optimization and in vitro–in vivo evaluation of febuxostat nanosuspension, International Journal of Pharmaceutics,2014;478:540–552.
7. Sarasija S, Singh C, Jena SK, Bagri S and Ahuja BK, Nanocrystals: A Novel Approachfor Drug Delivery, Department of Pharmaceutical Technology (Formulations), NIPER, 2014.
8. Srivalli Kale MR, Mishra B, Drug nanocrystals: A way toward scale-up, Saudi Pharmaceutical Journal, 2014; 24: 386–404.
9. Patel A. P., Patel J. k., Patel KS., Deshmukh AB., Mishra BR., A Review On Drug Nanocrystal A Carrier Free Drug Delivery, International Journal Of Ayurveda & pharmacy, 2011; 2(2):448-458.
10. Müller Rainer H, Junghanns Jens-Uwe A H, Nanocrystal technology, drug delivery and clinical applications, International Journal of Nanomedicine 2008; 3(3):295–309.
11. Nagarwal RC, Kumar R, Dhanawat M, Das N and Pandit J.K., Nanocrystal Technology in the Delivery of Poorly Soluble Drugs: An Overview, Current Drug Delivery, 2011.
12. Tuomela A, Hirvonen J and Peltonen L, Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability, Multidisciplinary Digital Publishing Institute, 2016; 8(16):1-18.
13. Pawar VK., Singh Y, Meher J G, Gupta S, Chourasia MK., Engineered nanocrystal technology: In-vivo fate, targeting and applications in drug delivery, Journal of Controlled Release, 2014.
14. Shete G, Jain H, Punj D, Prajapat H, Akotiya P, Bansal AK, Stabilizers used in nano-crystal based drug delivery systems,International Pharmaceutical Excipients Council, 2014; 5(4):184-209.
15. Shegokar R, Müller Rainer H., Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives, International Journal of Pharmaceutics, 2010; 399:129–139.
16. C.S Neethu, V.B Kavitha, B Dineshkumar, K Krishnakumar and John A, Nanocrystals Drug Delivery System – A Review, Current Research in Drug Targeting, 2014; 4(1):1-5.
17. Nekkanti V, Vabalaboina V and Pillai R, Drug Nanoparticles – An Overview,
18. Liu P, Nanocrystal formulation for poorly soluble drugs, Helsinki University Printing House, 2013.
19. Bansal S, Bansal M and Kumria R, Nanocrystals: Current Strategies and Trends, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2012; 3(1):406-419.
20. Peltonen L, Hirvonen J and Laaksonen T, Drug Nanocrystals and Nanosuspensions in Medicine, Division of Pharmaceutical Technology University of Helsinki, 2016.
21. Müller Rainer H., Gohla S and Keck Cornelia M., State of the art of nanocrystals – Special features, production, nanotoxicology aspects and intracellular delivery, European Journal of Pharmaceutics and Biopharmaceutics, 2011; 78:1-9.
22. Lu Yi, Li Ye and Wu Wei, Injected nanocrystals for targeted drug delivery, Acta Pharmaceutica Sinica B, 2016; 6(2):106–113.
23. Katteboinaa S, Chandrasekhar V S R, Balaji. S, Drug Nanocrystals: A Novel Formulation Approach for Poorly Soluble Drugs, 2009; 1(3):682-694.
24. Balamarkonda CH, Rao VS, Adamkhan P, Nama S, Brahmaiah B, A Review On Significance Of Nanocrystals In Drug Delivery, International Journal Of Pharmacy , 2013; 3(2):56-61.
25. Salazar J, Müller Rainer H, Möschwitzer Jan P, Combinative Particle Size Reduction Technologies for the Production of Drug Nanocrystals, Journal of Pharmaceutics Volume 2014.
26. Gao Y, Wang J, Wang Y, Yin Q, Glennon B, Zhong J, Ouyang J, Huang X And Hao H, Crystallization Methods for Preparation of Nanocrystals for Drug Delivery System, Current Pharmaceutical Design, 2015; 21:3131-3139.
27. CHANG TL, ZHAN H, LIANG D, LIANG JF., Nanocrystal technology for drug formulation and delivery, Higher Education Press and Springer-Verlag Berlin Heidelberg 2015; 9(1):1–14.
28. Sharma OP, Patel V, Mehta T, Nanocrystal for ocular drug delivery: hope or hype, Drug Deliv. And Transl. Res.DOI 10.1007/s13346-016-0292-0
29. Malamatari M, Taylor Kevin M.G., Malamataris S, Douroumis D and Kachrimanis K, Pharmaceutical nanocrystals: production by wet milling and applications, Drug Discovery Today, 2018; 2149:1-14.
30. Gauniya A, Mazumder R, Pathak K, Nanocrystals: A Challenge for Improved Drug Delivery, Asian Journal of Biochemical and Pharmaceutical Research, 2014; 4(3):282-292.
31. Raghvendra, Mishra A, A Review on Potential Applications of Nanocrystal Technology, Indian Journal of Pharmaceutical Science & Research, 2013; 3(1):9-13.
32. Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S, Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications, International Journal of Pharmaceutics, 2011; 42:1–10.
33. Möschwitzer JP., Drug nanocrystals in the commercial pharmaceutical development process, International Journal of Pharmaceutics, 2012.
34. Zhao J, Liu Y, Wang L, Zhou Y, Du J and Wang Y, Functional and Modified Nanocrystals Technology for Target Drug Delivery, Journal of Nanoscience and Nanotechnology, 2018; 18(8):5207–5221.
35. Gao L, Zhang D And Chen M , Drug Nanocrystals For The Formulation Of Poorly Soluble Drugs And Its Application As A Potential Drug Delivery System, Technology And Applications, 2008; 10:845–862.
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How to Cite
Saini, J., & Kumar, S. (2018). DEVELOPMENT OF NANOCRYSTAL FORMULATION WITH IMPROVED DISSOLUTION. Journal of Drug Delivery and Therapeutics, 8(5), 118-129.