IMPROVEMENT OF DISSOLUTION PROPERTIES OF ALBENDAZOLE FROM DIFFERENT METHODS OF SOLID DISPERSION

SOLID DISPERSION METHOD

  • A.K. Azad Advanced Drug Delivery Laboratory, 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.
  • K Jahan Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.
  • TS Sathi Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.
  • R Sultana Department of Pharmacy, Jagannath University, Dhaka-205, Bangladesh
  • SA Abbas Faculty of Pharmacy, Quest International University Perak, Malaysia
  • ABMH UddinUddin Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

Abstract

Poor aqueous solubility of drugs results in poor absorption and bioavailability.  The objective of Solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms.  Albendazole is a broad-spectrum antihelminthic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of our study was to improve the dissolution profile of Albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was HMPC K 100 LV at 1:10 ratio in solvent evaporation method. Among the carrier used here to conduct our study, HPMC K 100 LV showed better result for both kneading and solvent evaporation methods. And among the method employed here, solvent evaporation method showed better solubility of drug at 60 min also at 1:10 ratio which was 78.86%.

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Author Biographies

A.K. Azad, Advanced Drug Delivery Laboratory, 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

Advanced Drug Delivery Laboratory, 6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

K Jahan, Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.

Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.

TS Sathi, Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.

Department of Pharmacy, World University of Bangladesh, Dhaka-1205, Bangladesh.

R Sultana, Department of Pharmacy, Jagannath University, Dhaka-205, Bangladesh

Department of Pharmacy, Jagannath University, Dhaka-205, Bangladesh

SA Abbas, Faculty of Pharmacy, Quest International University Perak, Malaysia

Faculty of Pharmacy, Quest International University Perak, Malaysia

ABMH UddinUddin, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia.

References

1. Gupta P, Kakumanu VK, Bansal AK., Stability and solubility of celecoxib-PVP amorphous dispersions: a molecular perspective, Pharmaceutical Research, 2004; 21(10):1762–1769. DOI: 10.1023/B:PHAM.0000045226.42859.b8
2. Abdul-Fattah AM, Bhargava HN., Preparation and in vitro evaluation of solid dispersions of halofantrine, International Journal of Pharmaceutics, 2002; 235(2):17–33. DOI: 10.1016/S0378-5173(01)00941-3
3. Sinha S, Ali M, Baboota S, Ahuja A, Kumar A, Ali J., Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir, AAPS Pharm SciTech, 2010;11(2):518–527. DOI: 10.1208/s12249-010-9404-1
4. Jahan K, Sultana Z, Karim S, Ali H, Uddin J., Enhancement of dissolution properties of poorly water soluble drug loratadineby using different techniques of solid dispersion, World Journal of Science and Engineering, 2017; 2(1):103-108
5. Horter D, Dressman JB., Physiochemical properties on dissolution of drug in the gastrointestinal tract, Advance Drug Delivery Review, 1997; 25:3-14. DOI: 10.1016/S0169-409X(00)00130-7
6. Ahuja N, Katare OP, Singh B., Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water soluble drug using water soluble carriers, European Journal of Pharmaceutics and Biopharmaceutics, 2007; 65:26-38. DOI: 10.1016/j.ejpb.2006.07.007
7. Srinarong P, Faber JH, Visser MR, Hinrichs WLJ, Frijlink HW., Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of super disintegrates, European Journal of Pharmaceutics and Biopharmaceutics, 2009; 73:154-61. DOI: 10.1016/j.ejpb.2009.05.006
8. Albendazole, Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on September 23, 2015. Retrieved August 18, 2015.
9. Finch Roger G.; Greenwood David; Whitley Richard J.; Norrby S. Ragnar., Antibiotic and Chemotherapy E-Book. Elsevier Health Sciences. p. 101. ISBN 978-0-7020-4765-7, 2010.
10. Patel MM, Patel DM., Fast dissolving Valdecoxib tablets containing solid dispersion of Valdecoxib, Indian Journal of Pharmaceutical Science, 2006; 68(2):222-226. DOI: 10.4103/0250-474X.25719
11. Habib M.J., Pharmaceutical solid dispersion Technology, Technomic Publishing Company, Inc. Lancaster, Pennsylvania (U.S.A.). 2001, pp. 1-36.
12. Nelson E., Knoechel E.L., Hamlin W.E., Wagner J.G., Influence of the absorption rate of tolbutamide on the rate of decline of blood sugar levels in normal humans, International Journal of Pharmaceutics, 1962; 51:509-514. DOI: 10.1002/jps.2600510603
13. Lin S.L., Lachman L., Swartz C.J., Heubner C.F., Pre-formulation investigation I. Relation of salt forms and biological activity of an experimental antihypertensive. Journal of Pharmaceutical Sciences, 1972; 61(9):1418-1422. DOI: 10.1002/jps.2600610915
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How to Cite
Azad, A., Jahan, K., Sathi, T., Sultana, R., Abbas, S., & UddinUddin, A. (2018). IMPROVEMENT OF DISSOLUTION PROPERTIES OF ALBENDAZOLE FROM DIFFERENT METHODS OF SOLID DISPERSION. Journal of Drug Delivery and Therapeutics, 8(5), 475-480. https://doi.org/10.22270/jddt.v8i5.1942