• Shaika Saadia Zubedi Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001
  • Shahid Mohammed Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001


Oral drug delivery system is the most preferred route of administration for drug delivery. In the development of the drug delivery system many components play important role. Polymers are amongst those components which have evolved with the drug delivery system. Polymers are the macromolecule compound containing many monomer units joined to each other by bonds. The floating drug delivery systems (FDDS) become an additional advantage for drugs that are absorbed primarily in the upper segments of gastrointestinal (GI) tract, i.e., the stomach, duodenum and jejunum. The purpose of writing this review on floating drug delivery systems (FDDS) was to focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention and polymers used in floating Drug delivery systems. Polymers used in the drug delivery system are of two types Natural and Synthetic based on their origin. Both types of the polymers have some advantages and disadvantages. This particular article gives information about the different types of natural and synthetic polymer used in the drug delivery system. Natural polymers like guar gum, chitosan, xanthan gum, Gellan gum and sodium alginate are mentioned in the article. Synthetic polymers mentioned are HPMC, Eudragit, and Ethylcellulose.

Keywords: Floating Drug Delivery System, Polymers, Natural gums, HPMC.


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Author Biographies

Shaika Saadia Zubedi, Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001

Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001

Shahid Mohammed, Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001

Department of Pharmaceutics, Deccan School of Pharmacy, Hyderabad-500001


1. Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv 2006; 3(2):217- 33.
2. Garg R, Gupta GD. Progress in controlled gastroretentive delivery systems. Trop. J Pharm Res 2008; 7(3):1055-66.
3. Dixit N: Floating drug delivery system. Journal of Current Pharmaceutical Research 2011; 7:6-20.
4. Badoni A, Gnanarajan G and Ojha A: Review on gastro retentive drug delivery system. The Pharma Innovation 2012; 1:32-42.
5. Rouge N, Allemann E, Gex-Fabry M, Balant L, Cole ET, Buri P, Doelker E. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high density multipleunit capsule and an immediate-release tab containing 25 mg atenolol. Pharm Acta Helbetiae 1998; 73:81-7.
6. Streubel A, Siepmann J, Bodmeier R. Multiple unit Gastroretentive drug delivery: a new preparation method for low density microparticles. J Microencapsul 2003; 20:329-47.
7. Goole J, Vanderbist F, Aruighi K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms. Int J Pharm 2007; 334:35-41.
8. Shrma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm 2006; 313:150-58.
9. Santus G, Lazzarini G, Bottoni G, Sandefer EP, Page RC, Doll WJ, Ryo UY, Digenis GA. An in vitro- in vivo investigation of oral bioadhesive controlled release furosemide formulations. Eur J Pharm Biopharm 1997; 44:39-52.
10. Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastroretentive dosage forms. J Control Release 2003; 90:143-62.
11. Deshpande AA, Shah N, Rhodes CT, Malik W. Development of a novel controlled-release system for gastric retention. Pharm Res 1997; 14:815-19.
12. Chandel A, Chauhan K et al., Floating drug delivery systems: A better approach, International Current Pharmaceutical Journal 2012, 1(5):110-118.
13. Hirtz J, The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation, Br J Clin Pharmacol, 1985, 19:77S-83S.
14. Nayak AK, Maji R, Das B. Gastroretentive Drug Delivery Systems: A Review. Asian Journal of Pharmaceutical and Clinical Research 2010; 3(1):2- 9.
15. Moursy NM, Afifi NN, Ghorab DM, El-Saharty Y. Formulation and evaluation of sustained release floating capsules of Nicardipine hydrochloride. Pharmazie. 2003; 58:38Y43.
16. Erni W, Held K. The hydrodynamically balanced system: a novel principle of controlled drug release. Eur Neurol. 1987; 27:215Y275.
17. Menon A, Ritschel WA, Sakr A. Development and evaluation of a monolithic floating dosage form for furosemide. J Pharm Sci. 1994; 83:239Y245.
18. Oth M, Franz M, Timmermans J, Moes A. The bilayer floating capsule: a stomach directed drug delivery system for misoprostal. Pharm Res. 1992; 9:298Y302.
19. Rubinstein A, Friend D.R, Specific delivery to the gastrointestinal tract, in: Domb A. J (Ed.), Polymeric Site Specific Pharmacotherapy, Wiley, Chichester, 1994, 282-283.
20. Desai S. A Novel Floating Controlled Release Drug Delivery System Based on a Dried Gel Matrix Network [master’s thesis]. NY, St John’s University, 1984 Jamaica.
21. Iannuccelli V, Copp G, Sansone R, Ferolla G, Air compartment multiple-unit system for prolonged gastric residence part II in-vivo evaluation, International Journal of Pharmaceutics 1998; 174:55-62.
22. Tardi P, Troy H, (2002) European patent no.EP1432402
23. Gholap SB, Banarjee SK, Gaikwad DD, Jadhav SL, Thorat R M, Hollow microspheres: A Review, International Journal of pharma science research 2010; 1 (1):74-79.
24. Paterson RS, Omahony B, Eccleston GM, Stevens HNE, Fost er J, Murray JG, An assessment of floating raft formation in a man using magnetic resonance imaging, Journal of Pharm Pharmacol, 2008; 8(1).
25. Mayavanshi AV and Gajjar SS: Floating drug delivery system to increase gastric retention of drugs: A review. Research Journal of Pharmaceutical Technology 2008; 1(4):345-48.
26. Kumar, G. Natural Polymers in the Development of Floating Drug Delivery Systems: A Review. Int. J. Pharm. Life Sci., 2013; 2(4):165–178.
27. Darekar D. An overview on natural gum and its pharmaceutical application. International journal of universal pharmacy and biosciences, December, 2013; 2:535–547. DOI: 10.1016/j.biomag.2014.02.001.
28. Singh, A. kumar. Role of Natural Polymers Used In Floating Drug Delivery System Floating Drug Delivery System. J. Pharm. Sci. Innov, June, 2012; 1:11–15.
29. Raymond R, Sheskey P. Pharmaceutical press. Handbook of Pharmaceutical Excipient Sixth Edition, 2009.
30. Milanovic J., Manojlovic V., Levic S., Rajic N., Nedovic V. & Bugarski B. Microencapsulation of Flavors in Carnauba Wax. Sensors, 2010; 10:901-912.
31. Sanderson GR. Polysaccharides in Foods. Food Technology, 1981; 35, 50–56.
32. Phadtare D, Phadtare G, Asawat M. Hypromellose – A Choice of Polymer In Extended. World journal of pharmacy and pharmaceutical sciences, 2014; 3(9):551–566.
33. Hegyesi, D. Study of the Widely Used Ethylcellulose Polymer as Film Forming and Matrix Former Ph. D. Thesis Diána Hegyesi Pharmacist, 2016.
34. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery system: A review. Journal of Pharmaceutical Science and Technology 2011; 3(2):548-54.
35. Vedha H, Chaudhary J: The recent developments on gastric floating drug delivery system: An overview. Journal of Pharmaceutical Technology and Research 2010; 2(1):524-34.
36. Arunachalam A and Kishan GK: Floating drug delivery system: A review. International Journal of Research in Pharmaceutical Sciences 2011; 2(1):76-83.
37. Jain SK, Jain NK, Agrawal GP. Gastroretentive floating drug delivery: An overview. Drug Deliv Technol 2005; 5:7-15.
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How to Cite
Zubedi SS, Mohammed S. FLOATING TABLETS AND ITS POLYMERS. JDDT [Internet]. 15Oct.2018 [cited 18Sep.2021];8(5-s):16-4. Available from: http://jddtonline.info/index.php/jddt/article/view/1928