A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY

  • Narender G Naik Assistant Professor, Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, India
  • Shaym R Sunder Professor, University Institute of Chemical Technology, Osmania University, Hyderabad, India
  • Sateesh kumar Manchikanti Assistant Manager, Dr Reddy’s Laboratories, Miyapur, Hyderabad, Telangana, India

Abstract

About 60-70% of the drugs synthesized are poorly soluble and comes under BCS Class-II&IV. Now it is a challenging situation during the development of different dosage forms for pharmaceutical industries because solubility of the drug is the rate limiting step. Based on the solubility, the dissolution, bioavailability & therapeutic effect is dependent. To overcome this consequence a novel technique -Liquisolid compact is used by dissolving the poorly soluble drug in a non-volatile solvent that improves wettability & decreases the surface tension and ensures drug molecular dispersion in the formulation to increase the solubility of the drug. This admixture of drug loaded solution is blended with carrier adsorption & coating material (adsorption) that has free flowing and compressible powder properties.

Keywords: BCS-Class II drug, Liquisolid Compact, Non-Volatile Liquid, Coating material

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Author Biographies

Narender G Naik, Assistant Professor, Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, India

Assistant Professor, Jyothishmathi Institute of Pharmaceutical Sciences, Karimnagar, India

Shaym R Sunder, Professor, University Institute of Chemical Technology, Osmania University, Hyderabad, India

Professor, University Institute of Chemical Technology, Osmania University, Hyderabad, India

Sateesh kumar Manchikanti, Assistant Manager, Dr Reddy’s Laboratories, Miyapur, Hyderabad, Telangana, India

Assistant Manager, Dr Reddy’s Laboratories, Miyapur, Hyderabad, Telangana, India

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How to Cite
Naik, N., Sunder, S., & Manchikanti, S. kumar. (2018). A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY. Journal of Drug Delivery and Therapeutics, 8(5), 56-61. https://doi.org/10.22270/jddt.v8i5.1919