A PROMISING TECHNIQUE TO IMPROVE THE SOLUBILITY BY LIQUISOLID COMPACTION TECHNOLOGY
Abstract
About 60-70% of the drugs synthesized are poorly soluble and comes under BCS Class-II&IV. Now it is a challenging situation during the development of different dosage forms for pharmaceutical industries because solubility of the drug is the rate limiting step. Based on the solubility, the dissolution, bioavailability & therapeutic effect is dependent. To overcome this consequence a novel technique -Liquisolid compact is used by dissolving the poorly soluble drug in a non-volatile solvent that improves wettability & decreases the surface tension and ensures drug molecular dispersion in the formulation to increase the solubility of the drug. This admixture of drug loaded solution is blended with carrier adsorption & coating material (adsorption) that has free flowing and compressible powder properties.
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2. Rehmath JD, Shashiranjan D, Liquisolid compact of melaxicam:invitro and invivo evaluation Egyptian pharmaceutical journal 2017; 16:122-120
3. Brahamankar DM, Jaiswal SB, Bio pharmaceutics and pharmacokinetics .pg-296
4. Yankowsky SH, Technique is solubilisation , volume 12 marcel dekker , 122 – 137
5. Khan A.D., Singh L. Various techniques of bioavailability enhancement: a review. Journal of Drug Delivery and Therapeutics, 2016; 6(3):34-41. https://doi.org/10.22270/jddt.v6i3.1228
6. Martin A, Swarbrick J, Cammarata A. Solubility and distribution phenomena. Physical pharmacy. 2007; 212-222.
7. Dahiya S, Pathak K, dissolution enhancement of aceclofenac by cyclodextrin complexation, general of pharmaceutical research 2006; 5(4):99-102
8. Albers E., Mueller B.W. Cyclodexterin derivatives in pharmaceutics. crit. Rev Ther. Drug carr. syst. 1995; 12:311-337
9. Bhirud Y., Phalak H. Advances in solid dispersion technology and its applications in the development of solid dosage forms. Journal of Drug Delivery and Therapeutics, 2016; 6(6):40-47. https://doi.org/10.22270/jddt.v6i6.1316
10. Kala N., Shaikh M., Shastri D., Shelat P. A Review on Liquisolid Systems. Journal of Drug Delivery and Therapeutics, 2014; 4(3):25-31. https://doi.org/10.22270/jddt.v4i3.828
11. Thomas Reintjes. Solubility enhancement with BASF pharma polymers. Solubilizer comendium: available at http:// http://www.pharma-ingredients.basf.com/ October 2011.
12. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. Enhancement of dissolution rate of piroxicam using liquisolid compacts. II Farmaco. 2005; 60:361-365
13. N.R.Jadav,Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts,journal of drug delivery science and technology, 2017; 38:97-107
14. Boushra M. El-Houssieny,Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits, . BioScience Trends. 2010; 4(1):17-24.
15. Akinlade B, S Elkordy. Liquisolid system to improve the dissolution of furosemide. Sci Pharm 2010; 78:325-344
16. Gubbi SR, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sci 2010; 2:50-60.
17. Spireas S. Bioavailability improvement of clofibrate using liquisolid compact technology. APHA Annual Meeting 1995; 142-161.
18. Kulkarni AS, Aloorkar NH, Mane MS, Gaja JB. Liquiosolidsysyem:A Review. Int.journal of pharmaceutical sciences and nanotechnology, 2010; 3(1):795-802
19. Thakur N, Khokra SL, A Review on pharmaceutical application of liquisolid technicque,American J. of pharmate, 2011; 1(3).
20. Development of fast dispersible aceclofenac tablet: effect of functionality of super disintegrants. Indian J Pharm Sci. 2008; 70:180-185
21. Karmarkar A.B, Gonjari I.D, Hosmani A.H, Dhabale, P.N, Bhise S.B. Liquisolid tablets: a novel approach for drug delivery. Int. J. Health Res. 2009; 2:45-50.
22. Hugucchi and Connors, solubilization technicque
23. Izhar Ahmed Syed, The Liquisolid Technique: Based drug delivery system, Int. J. of pharm. sciences and drug research , 2012; 4(2):88-96
24. Utsav SP, Khushbu CP. Liquisolid Technique for Poorly Soluble Drugs Journal of Science and Innovative Research; 2(1):145-159.
25. .Manasa gangothri peddi, Novel drug delivery system: liquisolid compacts, molecular pharmaceutics and research
26. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. Enhancement of dissolution rate of piroxicam using liquisolid compacts. II Farmaco. 2005; 60:361-365
27. Pawar J., Jagtap R., Doijad R., Pol S., Desai J., Jadhav V., Jagtap S. Liquisolid compacts: a promising approach for solubility enhancement. Journal of Drug Delivery and Therapeutics, 2017; 7(4):6-11. https://doi.org/10.22270/jddt.v7i4.1466
28. Prajapati S., Maurya S., Das M., Tilak V., Verma K., Dhakar R. Dendrimers in drug delivery, diagnosis and therapy: basics and potential applications. Journal of Drug Delivery and Therapeutics, 2016; 6(1):67-92. https://doi.org/10.22270/jddt.v6i1.1190
29. Tiong N, Elkordy AA. Effects of liquisolid formulation on dissolution of naproxen. Eur J Pharm Biopharm 2009; 73:373-384.
30. Parajapati S., Maurya S., Das M., Tilak V.K., Verma K.K., Dhakar R.C. Potential application of dendrimers in drug delivery: a concise review and update. Journal of Drug Delivery and Therapeutics, 2016; 6(2):71-88. https://doi.org/10.22270/jddt.v6i2.1195
31. Yala P, Srinivasan S, Mahalingan K, Alladi S, Zalaki S. Solubility enhancement of a model etoricoxib drug using liquisolid compacts. Int J Biological Pharma Res 2012; 3(4):577-585.
32. Fahmy RH and Kassem MA. Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in-vitro and in-vivo evaluation. Eur J Pharm Biopharm 2008; 69:993–1003
33. Karmarkar AB, Gonjari ID, Hosmani AH, Dhabale PN, Bhise SB. Dissolution Rate Enhancement of Fenofibrate Using Liquisolid Tablet Technique. Part II: Evaluation of in-vitro dissolution profile comparison methods. Lat Am J Pharm 2009; 28(4):538-43.
34. Patel T, Patel L.D., Formulation of Fenofibrate Liquisolid Tablets Using Central Composite Design, Current Drug Delivery, 2014; 11:11-23 11
35. Vajir S. Solubility enhancement of diclofenac sodium by liquisolid technique. Int J universal Pharma life Sci 2012; 2(3):732-748
36. Spireas S, Sadu S, Grover R. In vitro release evaluation of hydrocortisone liquisolid tablets. J Pham Sci 1998; 87:867-872.
37. Sahil M, Gavali Shard S., Liquisolid compact :A New Technichnique for enhancement of drug dissolution, Int. J. of research in pharmacy and chemistry,2011, 1(3):705-713
38. Khaled KA, Asiri YA, In-vivo evaluation of liquisolid tablets in beagle dogs. Int. J. Pharm 2001; 222:1-6

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