GASTROPROTECTIVE NSAIDs

  • Mohammad Shahnaz Shivalik College of Pharmacy, Nangal, Punjab India
  • Parminder Kaur Shivalik College of Pharmacy, Nangal, Punjab India
  • DN Prasad Shivalik College of Pharmacy, Nangal, Punjab India

Abstract

NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic acid derivatives) with some antioxidants can be synthesized by esterification with various antioxidants of natural origin. The conjugates that show the retention or potentiating of anti-inflammatory activity with reduced ulcerogenic side effect could be potential gastroprotective co-drugs of NSAIDs.


Keyboards: NSAIDs, Gastroprotective, ROS, Natural antioxidants, Conjugates, Ulcerogenic

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Author Biographies

Mohammad Shahnaz, Shivalik College of Pharmacy, Nangal, Punjab India

Shivalik College of Pharmacy, Nangal, Punjab India

Parminder Kaur, Shivalik College of Pharmacy, Nangal, Punjab India

Shivalik College of Pharmacy, Nangal, Punjab India

DN Prasad, Shivalik College of Pharmacy, Nangal, Punjab India

Shivalik College of Pharmacy, Nangal, Punjab India

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How to Cite
Shahnaz, M., Kaur, P., & Prasad, D. (2018). GASTROPROTECTIVE NSAIDs. Journal of Drug Delivery and Therapeutics, 8(5), 141-145. https://doi.org/10.22270/jddt.v8i5.1905