FORMULATION AND EVALUATION OF SUMATRIPTAN IMMEDIATE RELEASE TABLETS

  • P Munija Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India
  • G Srikanth Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India

Abstract

The rationale of this investigation is to design an immediate release oral dosage of Sumatriptan succinate by using microcrystalline cellulose as filler, camphor and menthol as subliming agents by direct compression method .The basic objective of this dissertation is to develop an orodispersible tablet of sumatriptan succinate used in anti-migraine with an aim of reduces the lag time and providing faster onset of action to relief the acute migraine effect immediately. Disintegrates and disperses in oral cavity within 30 seconds without the need of drinking water. Has pleasant mouth feel and there is no after taste or grittiness. Successfully discriminates the ability of three superdisintegrants to promote drug dissolution and proposes a model formulation for disintegrants performance testing and quality control purposes. The formulation F6 containing 8% of CCS and 10% of menthol showed disintegration time of 18seconds after drying. Menthol as subliming agent was found to be most effective of all other subliming agents as it had showed drastic effect on the drug release.


Keywords: Sumatriptan succinate, sublimation, menthol, anti-migraine

Downloads

Download data is not yet available.

Author Biographies

P Munija, Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India

Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India

G Srikanth, Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India

Department of pharmaceutics, Vision College of Pharmaceutical Sciences and Research Boduppal, Hyderabad, Telangana, India

References

1. Nyol S., Gupta M. Immediate drug release dosage form: a review. Journal of Drug Delivery and Therapeutics, 2013; 3(2):155-161 https://doi.org/10.22270/jddt.v3i2.457
2. Patel K., Vyas J., Upadhyay U.. Formulation and evaluation of sustained release matrix tablets of nateglinide. Journal of Drug Delivery and Therapeutics, 2015; 5(5):19-25. https://doi.org/10.22270/jddt.v5i5.1130
3. Sutradhar KB, Formulation And Evaluation Of Taste Masked Oral Dispersible Tablets Of Domperidone Using Sublimation Method, International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4(2)
4. Mahajan HS, Kuchekar BS, Badhan AC, “Mouth dissolve tablets of sumatriptan succinate.” Ind. J. pharm. Sci. 2004; 238-240.
5. Wagh MA, Techniques used in orally disintegrating drug delivery system, International Journal of Drug Delivery 2010; 2:98-107
6. Momin S., Khan S., Ghadage D., Yadav A., Wagh A. Formulation and evaluation of bilayer tablets of propranolol hydrochloride. Journal of Drug Delivery and Therapeutics, 2017; 7(2):50-57. https://doi.org/10.22270/jddt.v7i2.1399
7. Vinay C., Ahmed, M. Formulation and evaluation of mucoadhesive buccal tablets of candesartan. Journal of Drug Delivery and Therapeutics, 2015; 5(5):56-63. https://doi.org/10.22270/jddt.v5i5.1135
8. Mallika T., Anand D., Harikrishna E. Isolation, characterization and investigation of starch phthalate as novel superdisintegrant in developing of acyclovir fast dissolving tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(1):33-42. https://doi.org/10.22270/jddt.v8i1.1550
9. Yeole CN, Darekar SS, Gupta A, Shrinivasan G. Formulation and evaluation of immediate release tablet of paroxetine HCl. J. Pharm. Res. 2010; 3:1736-8.
10. Bokshi B, Malakar A. Formulation and evaluation of allylestrenol immediate release tablets. Int. J. Pharm. Sci. Res. 2012; 3:1679-83.
11. Sawant T., Mane D. Dissolution method development with chromatographic method for determination of drug release in dissolution samples of ursodeoxycholic acid tablets. Journal of Drug Delivery and Therapeutics, 2018; 8(1):23-28. https://doi.org/10.22270/jddt.v8i1.1547
12. Dwivedi C., Rao S., Roy A., Saraf S., Kulsum U., Verma N., Pradhan D. Formulation and characterization of metformin hydrochloride sustained release matrix tablet containing cassia tora mucilage. Journal of Drug Delivery and Therapeutics, 7(6), 66-75. https://doi.org/10.22270/jddt.v7i6.1520
13. Patel DM, Patel MM, Optimization of fast dissolving etoricoxib tablet prepared by sublimation tech. Ind. J. pharm. Sci. 2008; 70:71-76.
Statistics
31 Views | 69 Downloads
How to Cite
Munija, P., & Srikanth, G. (2018). FORMULATION AND EVALUATION OF SUMATRIPTAN IMMEDIATE RELEASE TABLETS. Journal of Drug Delivery and Therapeutics, 8(5), 241-247. https://doi.org/10.22270/jddt.v8i5.1904