STUDY ON ANTICANCER EFFECT OF SYNTHETIC BIOGENIC SOURCE OF GERMACRENE A

  • Haiyan Cao Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Zihui Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Ruqi Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Boyang Mao Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Chen Liu Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Yutong Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Guowei Zhang Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Abstract

Objective: Based on obtaining germacrene A, which is the analogue of synthetic β-elemene, by means of synthetic biology,this experiment aims to explore the anti-tumor effect of germacrene A.


Results: After administration, the volume of T24 cells was significantly reduced. The shape of the T24 cells gradually changed from wedge-shaped and polygonal to round, and the T24 cells soon fell off, atrophied and disintegrated. After Tet blue staining, a large number of T24 cells after administration were observed to be dead; It was found by means of MTT assay that T24 cells were inhibited to varying degrees by the effects of different concentrations of germacrene A.


Conclusion: The above experimental results show that the synthetic biological source of germacrene A has obvious inhibitory effect on bladder cancer T24 cells, and this effect has obvious time and concentration dependence.


KeywordsGermacrene A; Synthetic drugs; Antitumor; β-elemene

Keywords: Germacrene A, β-elemene

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Author Biographies

Haiyan Cao, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Zihui Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Ruqi Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Boyang Mao, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Chen Liu, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Yutong Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Guowei Zhang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Department of Traditional Chinese Medicine, Hebei University, Baoding, China

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How to Cite
Cao, H., Li, Z., Li, R., Mao, B., Liu, C., Li, Y., & Zhang, G. (2018). STUDY ON ANTICANCER EFFECT OF SYNTHETIC BIOGENIC SOURCE OF GERMACRENE A. Journal of Drug Delivery and Therapeutics, 8(5), 421-429. https://doi.org/10.22270/jddt.v8i5.1896