EFFECT OF METOSARTAN ON MALE REPRODUCTIVE POTENTIAL IN NORMAL AND HYPERTENSION INDUCED RATS
Hypertension is one of the long term medical problems in world leading to mortality of 18% globally. Epigenetic modifications like gene regulation, DNA histone modification and methylation patterns are mostly affected during Hypertension condition and need to be carefully monitored. So, metosartan is the one of the antihypertensive drug used to study its effects on genome especially in invivo condition. Metosartan doesn’t affect the chromatin integrity in hypertensive rats but reduces the sperm count drastically and reaches up to zero at 1.25mg/ml concentration. Majorly the drug affects the sperm count but not the maturation of sperm. In hypertension condition the sperms are aggregated in to complex where as in metosartan treated group invitro lead to severe looping of sperms and resulted in formation of apoptotic bodies. In normal rats excessive DNA fragmentation is seen in metosartan treated group and treatment with RNase A along with metosartan invitro restored the chromatin integrity but failed to give promisive results in invivo condition. So, study of genome integrity in hypertensive patients treated with metosartan is compulsory as it affects chromatin integrity adversely in invitro condition in normal rats.
Keywords: Hypertension, Genome integrity, Azoospermia, Teratozoospermia, Metosartan
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