• Jyoti Jyoti
  • Sandeep Kumar ASBASJS Memorial College of Pharmacy, Bela, Ropar, Punjab, India


Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles and posses large porous surface area. Furthermore, they may enhance stability, reduce side effects, improve patient compliance and modify drug release. Microsponges are the polymer-based microspheres system that has the capacity to entrap a wide variety of substances, and can then be incorporated into a different formulation.

Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.


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Author Biographies

Jyoti Jyoti

ASBASJS Memorial College of Pharmacy, Bela, Ropar, Punjab, India

Sandeep Kumar, ASBASJS Memorial College of Pharmacy, Bela, Ropar, Punjab, India

ASBASJS Memorial College of Pharmacy, Bela, Ropar, Punjab, India


1. Mantry Shubhrajit, Bagchi Arnab, Das Sujit, Das Sudip, Microsponge as A Novel Stratergy of Drug Delivery System, Universal Journal of pharmaceutical science and research, 2015; 1(1):32-38.
2. Kumar Jaya raja, Muralidharan Selvadurai and Parasuraman Subramani, Evaluation of Antifungal Activity of Sustained Release Microsponge Enriched Fluconazole Gel for Penile Candidiasis in Male Rats, International Journal of PharmTech Research, 2014;6(6):1888-1897
3. Avhad Pawan S. and Patil Prashant B., A New Era In Topical Formulations – Microsponge Drug Delivery System International Journal Of Pharmaceutical Science And Research, 2016; 7(7):2756-2761.
4. Muralidharan Selvadurai, Kumar Jaya raja, Ramasamy Sanggetha, Microsponges Enriched Gel (MEGs): A Novel Strategy for Opthalmic Drug Delivery System Containing Ketotifen, Journal of Pharmaceutical Science. & Research 2013; 5(4):97–102.
5. Pathan Adil, Sanghshetti, Microsponge in Drug Delivery: A Review, International Journal of Parenteral and Dermatology, 2017; 1(1):32-35.
6. Deshwal Shikha and Saxena Ashwin Kumar, Micreosponge Delivery System: An Overview International Journal of Biopharmaceutics. 2014; 5(1):39-46.
7. Jadhav Namrata, Patel Vruti, Mungekar Siddesh, Bhamare Gaurav, Karpe Manisha, Kadams Vilasrao, Microsponge Delivery System: An updated review, current status and future prospects Journal of Scientific and Industrial Research, 2013; 2(6):1097-1110.
8. Gupta Akashdeep, Dhyani Archana and Juyal Divya , Microsponges laden gels for topical delivery: A novel approach The Pharma Innovation Journal 2016; 5(6): 39-43.
9. Kawashima Yoshiaki , Niwa Toshiyuki , Takeuchi Hirofumi , Hino Tomoaki , Ito Yoji, Control of Prolonged Drug Release and Compression Properties of Ibuprofen Microsponges with Acrylic Polymer, Eudragit RS by Changing their Intraparticle porosity, Chemical & Pharmaceutical bulletin 1992;40(1):196-201.
10. Kaity Santanu, Maiti Sabyasachi, Ghosh Ashoke Kumar , Pal Dilipkumar, Ghosh Animesh , Banerjee Subham, Microsponge: A Novel Strategy For Drug Delivery System, Journal of Advanced Pharmaceutical Technology and Research, 2010; 1:283-290.
11. Nanda Shivani, Microsponge drug delivery syatem: an overview, World Journal of Pharmacy and Pharmaceutical sciences, 2013; 2(3):1032-1043.
12. Patil Shital S., Dandekar Vaishali, Kale Asawari And Barhate Dr. S. D., Microsponge Drug Delivery System: An Overview European Journal of pharmaceutical and Medical Research, 2016;3(8):212-221
13. Aritomi H, Yamasaki Y, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. Journal of Pharmceutical Science and Technology, 1996; 56(1):49-56.
14. Charde M. S. , Ghanawat P. B., Welankiwar A. S., Kumar J. And Chakole R. D. Microsponge A Novel New Drug Delivery System: A Review International Journal Of Advances in Pharmaceutics, 2013; 2(6).
15. Jagtap S.C, Karale A.A and Ambekar A.W Microsponge:A Novel Topical Drug Delivery System, Journal Of Drug Delivery Research, 2014; 3(4).
16. Vikrant K, Nikam, Dolas RT, Somwanshi SB, Gaware V.M., Kotade K.B., Dhamak K.B., Khadse A.N. and Kashid V.A., Microparticles: a novel approach to enhance the drug delivery - a review, IJPRD, 2011; 3(8):170-183.
17. Chainesh N. Shah And Dhiren P. Shah Microsponges: A Revolutionary Path Breaking Modified Drug Delivery of Topical Drugs International Journal of Pharmaceutical Research, April-June 2014; 6(2).
18. Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Gary P, Martin, Nokhodchi A., The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies, International Journal of Pharmaceutics, 2006; 308(1-2):124-132.
19. Mandava Shyam Sunder And Thavva Vedavathi, Novel Approach: Microsponge Drug Delivery System International Journal Of Pharmaceutical Science And Research, 2012; 3(4).
20. Comoglu T, Gonul N, Baykara T, The effects of pressure and direct compression on tabletting of microsponges, International Journal of Pharmaceutics, 2002; 242(1-2):191-5.
21. Patel Archana, Upadhyay Pratik, Trivedi Jatin, Shah Shreeraj And Patel Jaymin Microsponges as the versatile tool for Topical route: A Review, International Journal of Pharmaceutical Science And Research, 2012; 3(9):2926-2937.
22. Aloorkar N.H., Kulkarni A.S., Ingale D.J. and Patil R.A., Microsponges as Innovative Drug Delivery Systems, International Journal of Pharmaceutical Sciences and Nanotechnology, 2012; 5(1).
23. Mahajan AG, Jagtap LS and Chaudhary AL, Swami Sima P, Formulation & evaluation of Microsponge drug delivery system using Indomethacin. International Research Journal of Pharmacy 2011; 2(10): 64-69
24. Kaur R., Kaur S. Role of polymers in drug delivery. Journal of Drug Delivery and Therapeutics, 2014; 4(3):32-36.
25. Joshi Garish, kaur Rajandeep and kaur Harpreet, International Research Journal of Pharmaceutical and Biosciences, 2016; 3(1):01- 11.
26. Saboji JK, Manoi FV, Gadad AP and Patel BD: Formulation & evaluation of ketoconazole microsponge gel by Quasi emulsion solvent diffusion. Journal of Cell & Tissue Research 2011; 11:2691-2696.
27. Kumari Pushpa, Mishra Shashi Kiran, A Comprehensive Review On Novel Microsponges Drug Delivery Approach, Asian Journal of Pharmaceutical and Clinical Research, 2016; 9(1):25-30.
28. Kavya Lalitha S, Shankar M, Likhitha D, Dastagiri J, Niranjan Babu M, A Current View on Microsponge Drug Delivery System European Journal of Molecular Biology And Biochemistry 2016; 3(1):33-38.
29. Nikam Vikrant K., RT Dolas, SB Somwanshi, VM Gaware, KB Kotade, KB Dhamak, AN Khadse and VA Kashid, Microparticles: a novel approach to enhance the drug delivery - a review, International Journal of Pharmaceutical Research and Development, 2011;3(8):170- 183.
30. Gandhi Sanket, Dol Hemalata, Ghorpade Sagar, Microsponge: A Prominent Strategy to Accelerate Performance of Topical Formulation, International Journal of Pharmacy and Pharmaceutical Research, 2016; 7(3).
31. Rajurkar VG, Tambe AB and Deshmukh VK, Topical Anti-Inflammatory Gels of Naproxen Entrapped in Eudragit Based Microsponge Delivery System, Journal of Advvanced Chemical Engineering, 2015, 5:2.
32. Nawal A. Rajab, Mohammad S. Jawad Formulation and In Vitro Evaluation of Piroxicam Microsponge as a Tablet, International Journal of Pharmacy And Pharmaceutical Sciences, 2016; 8(2).
33. Jain N, Sharma PK, Banik A, Recent advances on microsponge delivery, International journal of Pharmaceutical Sciences Review and Research, 2011:8(2).
34. Deore Mayuri B, Salunkhe K.S., Pawbake G., Chaudhari S.R. and Gaikwad P.R.Microsponges As A Modified Drug Delivery System World Journal of Pharmaceutical Research, 4(3):657-667.
35. Engla G., Soni L., Dixit V. Sustained release delivery of repaglinide by biodegradable microspheres. Journal of Drug Delivery and Therapeutics, 2017; 7(7):77-80.
36. Upadhye Shashikant S., Kothali B.K., Apte A.K., Patil A.A., Danole A.B., A Review On Microsponge Drug Delivery System, International Journal of Pharmaceutical Research and Bio-science, 2016; 5(1):152-166.
37. Yerram Chandramouli, Shaik Firoz, B. Rubia Yasmeen, Amaravathi Vikram, B. Mahitha, U. Aruna Microsponges: A Novel Drug Delivery System For Controlled Delivery Of Topical Drugs International Journal Of Pharmaceutical Research & Analysis, 2012; 2(2):79-86.
38. Jain Vikas and singh Ranjit, Dicyclomine-loaded eudragit based microsponge with potential for colonic delivery Preparation and characterization, Tropical Journal of Pharmaceutical Research, 2010; 9(1):67-72.
39. Orlu M , Cevher E , Araman A Design and evaluation of colon specific drug delivery system containing Flurbiprofen microsponges, International Journal of Pharmaceutics, 2006; 318(1-2):103-117.
40. Ade Pavan Kumar, Bhalerao Pravin, Khan Arshiya, Shahi S.R, Tadwee Imran Microsponge Drug Delivery System: A Review, International Journal of Parenteral And Dermatology, 2017; 1(1):33-44
41. Singh S., Koland M. Formulation and evaluation of pulsatile drug delivery systems of glipizide for the management of type-II diabetes mellitus. Journal of Drug Delivery and Therapeutics, 2016; 6(1):11-18.
42. Embil K. and Nacht, The Microsponge delivery system: a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives, Journal of Microencapsulation 1996; 13(5):575-88.
43. Kapoor D, Vyas RB, Lad C, Patel M, Tyagi B, A Review On Microsponge Drug Delivery System Journal of Drug Delivery and Therapeutics, 2014; 4(5):29-35.
44. Kumar Saurabh, Tyagi L.K., and Singh Dashrath, Microsponge Delivery System (Mds): A Unique Technology For Delivery of Active Ingredients International Journal of Pharmaceutical Science and Research, 2011; 2(12):3069-3080.
45. Dasthagiri S, Jagadeesh P, Thirumallesh Naik SB, Nethravani G, Over Review of Microsponges – Advanced Novel Technology, World Journal of Pharmacy And Pharmaceutical Sciences, 5(2):414-426.
46. Kapoor D., Patel M., Vyas R., Lad C., Lal B. Site specific drug delivery through nasal route using bioadhesive polymers. Journal of Drug Delivery and Therapeutics, 2015; 5(1):1-9.
47. Shaheen S Z, Bolla K, Vasu K & Singara C M A., Antimicrobial activity of the fruit extracts of Coccinia indica, African Journal of Biotechnology, 2009; 8(24):7073-707.
48. Tile Manisha K. And Pawar A.Y., Microsponges: A Novel Strategy For Drug Delivery, International Journal of Pure and Applied Bioscience, 2015; 3(1):224-235
49. Francesco Trotta, Marco Zanetti1 and Roberta Cavalli, Cyclodextrin-based nanosponges as Drug carrier. Beilstein Journal of Organic Chemistry, 2012; 8:2091–2099.
50. Jain V., Singh R. Development and characterization of eudragit RS 100 loaded microsponges and its colonic delivery using natural polysaccharides. Acta Poloniae Pharmaceutica - Drug Research, 2010; 67:407-415.
51. Moin Afrasim , Deb Tamal K. , Osmani Riyaz Ali M., Bhosale Rohit R. , and Hani Umme, Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy, Journal of Basic and Clinical Pharmacy, 2016; 7(2):39–48.
52. Srivastava R, Pathak K, Micosponges: a futuristic approach for oral drug delivery, Expert Opinion on Drug Delivery, 2012; 9(7): 863-878.
53. Rastogi V., Shukla S., Singh R., Lal N., Yadav P. Microspheres: a promising drug carrier. Journal of Drug Delivery and Therapeutics, 2016; 6(3):18-26.
54. Gandhi Arijit, Jana Sougata, Sen Kalyan Kumar Tailoring Effect of Microsponge For Targeted Drug Delivery Journal of Scientific and Innovative Research 2013; 2 (6):1073-1082
55. D’souza John I. and More Harinath N., Topical Anti-Inflammatory Gels of Fluocinolone Acetonide Entrapped in Eudragit Based Microsponge Delivery System, Research Journal of Pharmacy and Technology, 2008; 1(4):502-506.
58. Jain NK, Advances in controlled and novel drug delivery, New Delhi: CBS Publishers and Distributors, 2003: 89-91.
59. Martin A., Swarbrick J. & Cammarrata A., In: Physical Pharmacy- Physical Chemical Principles in Pharmaceutical Sciences. 3rd Ed., 1991 pp. 527
60. Vyas SP and Khar RK: Targeted & controlled drug delivery. 1st edition, CBS Publication, 2002.
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How to Cite
Jyoti J, Kumar S. INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY. JDDT [Internet]. 6Sep.2018 [cited 31May2020];8(5):28-4. Available from: