ANTIPLASMODIAL ACTIVITY OF CAESALPINIA CRISTA SEED EXTRACTS
Objective: To evaluate antiplasmodial activity of Caesalpinia crista seed extracts
Methods: Antiplasmodial activity of the seed extracts of Caesalpinia crista against rodent malaria infections in chloroquine sensitive Plasmodium falcipuram strain was investigated, and oral acute toxicity of seed extracts of Caesalpinia crista was also evaluated.
Results: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The alcoholic extract was found no toxicity in wistar rats and the oral LD50 was determined to be greater than 5000 mg/kg.
Conclusion: Seed extracts of Caesalpinia crista extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents
Keywords: Plasmodium falcipuram, Caesalpinia crista, Plant extracts, Phytochemicals, Toxicity tests, malaria.
2. Banskota, A.H., F. Attamimi, T. Usia, T.Z. Linn, Y. Tezuka, S.K. Kalauni and S. Kadota. Novel norcassane-type diterpene from the seed kernels of Caesalpinia crista. Tetrahedron Lett., 2003; 44:6879-6882.
3. Harborne, A.J. Phytochemical Methods. Chapman and Hall, London, New York, Tokyo 1973; 1-33.
4. Kalauni, S.K., S. Awale, Y. Tezuka, A.H. Banskota, T.Z. Linn and S. Kadota. Cassane and nor cassane type diterpenes of Caesalpinia crista from Myanmar. J. Nat. Prod., 2004; 67:1859-1864
5. Swapna Reddy M, Ramya Kuber B. Evaluating the antiinflammatory potential of isolated constituents from seeds of caesalpinia crista .Journal of pharma Research 2017; 6( 2):77-78.
6. Organisation for Economic Co-operation and Development. Guidelines on Acute Oral Toxicity. OECD guideline for testing of chemicals. Acute oral toxicity-acute toxic class method. OECD Guidelines for the Testing of Chemicals 2010; 1(4):1-14.
7. OECD series on principles of good laboratory practice and compliance monitoring. Ann Institute Super Sanita 1997; 33(1):1-172.
8. NIH (National Institutes of Health). Guide for the Care and Use of Laboratory Animals. 8th ed. Bethesda MD: National Institutes of Health, 2011: 82-83.
9. David AF, Philip JR, Simon RC, Reto B, Solomon N. Antimalarial drug discovery: Efficacy models for compound screening. Nat Rev 2004; 3(6):509-520.
10. Akuodor GC, Anyalewech NA, Ikoro NC, et al. Evaluation of antiplasmodial activity of Berlina grandiflora leaf extract against Plasmodium falcipuram in wistar rats. Afr J Microbiol Res 2010; 4(21):2211-2214.
11. Mbah CC, Akuodor GC, Anyalewechi NA, Iwuanyanwu TC, Osunkwo UA. In vivo antiplasmodial activities of alcoholic extract of Bridelia ferruginea stem bark against Plasmodium falcipuram in wistar rats. Pharmaceutical Biology 2012; 50(2):188-192.
12. Iwuanyanwu TC, Akuodor GC, Essien AD, et al. Evaluation of antimalarial potential of aqueous stem bark extract of Caesalpinia crista (Bombacaceae). Eastern J Med 2012; 17(2):72-77.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).