ANTIPLASMODIAL ACTIVITY OF CAESALPINIA CRISTA SEED EXTRACTS

  • M. Swapna Reddy a Sri Padmavathi Mahila Visvavidyalayam, Tirupathi-517502, A.P, India b Vaagdevi Pharmacy College, Bollikunta, Warangal, India
  • B. Ramya Kuber Associate Professor, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visva Vidyalayam (Women’s University), Tirupati-517502, A.P, India.

Abstract

Objective: To evaluate antiplasmodial activity of Caesalpinia crista seed extracts


Methods:  Antiplasmodial activity of the seed extracts of Caesalpinia crista against rodent malaria infections in chloroquine sensitive Plasmodium falcipuram strain was investigated, and oral acute toxicity of seed extracts of Caesalpinia crista was also evaluated.


Results: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The alcoholic extract was found no toxicity in wistar rats and the oral LD50 was determined to be greater than 5000 mg/kg.


Conclusion: Seed extracts of Caesalpinia crista extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents


Keywords: Plasmodium falcipuram, Caesalpinia crista, Plant extracts, Phytochemicals, Toxicity tests, malaria.

Keywords: Plasmodium falcipuram, Caesalpinia crista, Plant extracts, Phytochemicals, malaria

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Author Biographies

M. Swapna Reddy, a Sri Padmavathi Mahila Visvavidyalayam, Tirupathi-517502, A.P, India b Vaagdevi Pharmacy College, Bollikunta, Warangal, India

a Sri Padmavathi Mahila Visvavidyalayam, Tirupathi-517502, A.P, India

b Vaagdevi Pharmacy College, Bollikunta, Warangal, India

B. Ramya Kuber, Associate Professor, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visva Vidyalayam (Women’s University), Tirupati-517502, A.P, India.

Associate Professor, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visva Vidyalayam (Women’s University), Tirupati-517502, A.P, India.

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How to Cite
Reddy, M. S., & Kuber, B. R. (2018). ANTIPLASMODIAL ACTIVITY OF CAESALPINIA CRISTA SEED EXTRACTS. Journal of Drug Delivery and Therapeutics, 8(5), 354-357. https://doi.org/10.22270/jddt.v8i5.1880