ANTIDIABETIC EFFICACY OF ETHANOLIC EXTRACT OF HOLARRHENA ANTIDYSENTERICA SEEDS IN STREPTOZOTOCIN â€“ INDUCED DIABETIC RATS AND ITâ€™S INFLUENCE ON CERTAIN BIOCHEMICAL PARAMETERS
Holarrhena antidysenterica commonly known as kurci, kurchi or kutaj is being used from ancient time in the treatment of amoebiasis, chronic bronchitis, diabetes and locally for boils and ulcers. Present study was designed to evaluate the hypoglycemic effect of ethanolic extract of its seeds in streptozotocin â€“ induced diabetic rats and its effect on serum cholesterol, triglyceride, aspartate transaminase (AST), alanine transaminase (ALT), alkaline transferase (ALP), total protein, urea, creatinine and uric acid. Hyperglycemia was induced in overnight fasted albino rats by single intraperitoneal injection of streptozotocin (STZ) in 40 mg/kg body weight dose. Â The extract was administered orally at a dose of 300 and 600 mg/kg body weight for 28 days. Oral glucose tolerance test done in normal rat. Glibenclamide was the reference drug used in the treatment.Â Significant antihyperglycemic effect was observed in ethanolic extract treated diabetic rats. There was gain in body weight and above mentioned biochemical parameter were reversed to near normal in ethanolic extract treated rats as compared to diabetic control rats. This is an indication of its potent antidiabetic effect.
Key words: Hypoglycemic, streptozotocin, Holarrhena antidysenterica, diabetic
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