QUERCETIN NANOPARTICLES REPRESSED LIVER AND BRAIN TOXICITIES INDUCED BY TARTRAZINE IN RATS

  • G. Mohamed Eman Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
  • M. Abo-laila Ibrahim Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
  • A.M. Hendawy Hassan Analytical and Inorganic Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
  • Mohammad F Ebtehal Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt. P.O. BOX 29

Abstract

Tartrazine (TZ) is an azobenzene artificial yellow dye for foods, drugs, and cosmetics. Quercetin is member of the flavonoid family. The current study investigated the protective effect of quercetin nanoparticles (QNPs) against TZ. Male albino rats were divided into group1:  control, group 2: TZ (50 mg/kg), group 3: QNPs (5 mg/kg), and group 4: QNPs+TZ. The results of the present study revealed that, the oral administration of TZ dye caused a significantly increased liver biomarkers. Also, a marked effect on lipid profile and blood parameters were shown. In addition TZ induced an elevation in the examined oxidative stress biomarkers and decrease in glutathione peroxidases and acetylcholine esterase. TZ diminished exploration and rearing in open field test as well as elevation in GABA content and apoptosis as well as changes in tissues by histopathological examination. In fact, the results showed good influence of QNPs in improving injuries associated with TZ administration.


Keywords:  Tartrazine Dye, Quercetin Nanoparticles, Liver-Brain injuries.

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Author Biographies

G. Mohamed Eman, Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

M. Abo-laila Ibrahim, Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

A.M. Hendawy Hassan, Analytical and Inorganic Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Analytical and Inorganic Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Mohammad F Ebtehal, Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt. P.O. BOX 29

Pharmacology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt. P.O. BOX 29

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How to Cite
Eman, G. M., Ibrahim, M. A.- laila, Hassan, A. H., & Ebtehal, M. F. (2018). QUERCETIN NANOPARTICLES REPRESSED LIVER AND BRAIN TOXICITIES INDUCED BY TARTRAZINE IN RATS. Journal of Drug Delivery and Therapeutics, 8(5), 230-240. https://doi.org/10.22270/jddt.v8i5.1865