Antioxidant and antifungal activity of Geophila repens (L.) I. M. Johnst. (Rubiaceae)

  • BK Sahana Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India
  • Shahneel Akhilesha Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India
  • GS Priyanka Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India
  • TR Prashith Kekuda Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Abstract

Objectives: The present study was conducted to investigate the potential of leaf extract of Geophila repens (L.) I.M. Johnst. (Rubiaceae) to exhibit antioxidant and antifungal potential.


Methods: Extraction of powdered leaf material was carried out by maceration process using methanol. Antioxidant activity of leaf extract was assessed by DPPH free radical scavenging assay and ferric reducing assay. Antifungal activity of leaf extract was determined by Poisoned food technique.


Results: Leaf extract was shown to scavenge DPPH radicals dose dependently with IC50 value of 51.39µg/ml. An increase in the absorbance on increasing concentration of leaf extract indicated ferric reducing activity. The extract showed more or less similar inhibitory activity against Aspergillus niger and Bipolaris sp. (>50% inhibition).


Conclusion: The results of the study indicate that leaf extract possesses bioactive principles with activity against oxidative damage and seed-borne fungi which are to be purified and screened for antioxidant and antifungal activity.


Keywords: Geophila repens, Maceration, DPPH, Ferric reducing, Seed-borne fungi, Poisoned food technique

Keywords: Geophila repens, DPPH, erric reducing

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Author Biographies

BK Sahana, Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Shahneel Akhilesha, Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

GS Priyanka, Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

TR Prashith Kekuda, Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S campus, Balraj Urs road, Shivamogga-577201, Karnataka, India

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How to Cite
Sahana, B., Akhilesha, S., Priyanka, G., & Prashith Kekuda, T. (2018). Antioxidant and antifungal activity of Geophila repens (L.) I. M. Johnst. (Rubiaceae). Journal of Drug Delivery and Therapeutics, 8(5), 268-272. https://doi.org/10.22270/jddt.v8i5.1837