FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL
Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules). In such situation transdermal drug delivery remains the most preferential mode of administration. But, stratum corneum forms the most formidable barrier for the penetration of drug through skin. To overcome the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has involved increasing attention in recent years. The aim of the present study was to statistically optimize the vesicular formulations (Transfersomes) for enhanced skin delivery of a model drug Clindamycin Phosphate.
Keywords: Transfersomes, Acne vulgaris, Clindamycin Phosphate
2. Cunliffe WJ. The sebaceous gland and acne-40 years on. Dermatology. 1998; 196:9–15.
3. Leyden JJ. Therapy for acne vulgaris. N Engl J Med. 1997; 336:1156–1162.
4. Gollnick H, Schramm M. Topical drug treatment in acne. Dermatology. 1998; 196:119–125.
5. Swathi, Sowjanya et al, Various aspects of Pharmaceutical Preformulation: A Review, PHARMANEST: An International Journal of Advances in Pharmaceutical Sciences. 2013; 4(2):171-190.
6. Bharate SS, Bharate SB, Bajaj AN, “Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review,” Journal of Excipients and Food Chemicals, 2010; 1(3):3–26.
7. Lachman L, Liebermann HA, Kanig JL, The Theory and Practice of Industrial Pharmacy, Stipes Publishing, 3rd edition, 1986
8. Aulton ME, Pharmaceutics: The Science of Dosage Form Design, Churchill Livingstone, London, UK, 2006.
9. Martin EW, Remington’s the Science and Practice of Pharmacy, Lippincott Williams & Wilkins, 21st edition, 2005.
10. Soni P, Saini T. Non-Ionic surfactant vesicles (niosomes) based novel ophthalmic formulation of timolol maleate. Journal of Drug Delivery and Therapeutics, 2017; 7(7):59-61. https://doi.org/10.22270/jddt.v7i7.1587
11. Jain S, Jain P, Maheshwari UR, Jain N. Transfersomes – A novel vesicular carrier for enhanced transdermal delivery: Development, characterization, and performance evaluation. Drug Dev Ind Pharm 2003; 29:1013 26
12. Duangjit S, Opanasopit P, Rojanarata T, Ngawhirunpat T. Evaluation of meloxicam loaded cationic transfersomes as transdermal drug delivery carriers. AAPS PharmSciTech 2013;14:133 40
13. Jaiswal P, Kesharwani S, Kesharwani R, Patel D, Ethosome: A new technology used as topical & transdermal delivery system. Journal of Drug Delivery and Therapeutics, 2016; 6(3):7-17. https://doi.org/10.22270/jddt.v6i3.1245
14. Shingade G. Review on: Recent trend on transdermal drug delivery system. Journal of Drug Delivery and Therapeutics, 2012; 2(1):66-75. https://doi.org/10.22270/jddt.v2i1.74
15. Modi CD and Bharadia PD, “Transfersomes: New Dominants for Transdermal Drug Delivery”, American Journal of Pharmtech Research, 2012; 2(3):71-91.
16. Farooqui N, Kar M, Jain S. Development and evaluation of proniosomes as drug carriers for transdermal delivery of ketorolac tromethamine. Journal of Drug Delivery and Therapeutics, 2017; 7(7):38-40. https://doi.org/10.22270/jddt.v7i7.1580
17. Nimker V, Jamal H, Ghosh P, Jain S, Beotra A. Liposomes: drug delivery system or possible doping agent?. Journal of Drug Delivery and Therapeutics, 2017; 7(1):25-29. https://doi.org/10.22270/jddt.v7i1.1369
18. Cevc G, Blume G, Scha¨tzlein A., Transferosomes-mediated transepidermal delivery improves the regiospecificity and biological activity of corticosteroids in vivo. J Control Rel., 1997, 45, 211–26.
19. Hanpramukkun N., Kongmuang S., Chansiri G., The stability of clindamycin phosphate in w/o/w multiple emulsions, Int J Pharm Sci Tec, 2009, 3(2), 1-7.
20. Jivrani Shilpa D, Patel Vijay K, Formulation, Development And Evaluation of Niosomal Drug Delivery System For Clindamycin Phosphate, Pharma Science Monitor, 2014, 5(2), 256-274.
21. Mishra M. and Biswal P., Complexation, Optimization, Formulation development and characterization of clindamycin phosphate gel using zinc acetate dehydrate, international jouranal of pharmacy, 2012; 2(3):472-486.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).