FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL

  • Neha Thakur Nri Institute of Pharmacy, Bhopal, M.P., India
  • Prabhat Jain Scan Research Laboratories, Bhopal, M.P., India
  • Vivek Jain Nri Institute of Pharmacy, Bhopal, M.P., India

Abstract

Transfersomes are particularly optimized, ultradeformable (ultraflexible) lipid supramolecular aggregates, which are able to penetrate the mammalian skin intact. Transfersome is a type of carrier system which is capable of transdermal delivery of low as well as high molecular weight drugs. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. Acne vulgaris is a disease of the pilosebaceous follicle characterized by non-inflammatory (open and closed comedones) and inflammatory lesions (papules, pustules, and nodules). In such situation transdermal drug delivery remains the most preferential mode of administration. But, stratum corneum forms the most formidable barrier for the penetration of drug through skin. To overcome the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has involved increasing attention in recent years. The aim of the present study was to statistically optimize the vesicular formulations (Transfersomes) for enhanced skin delivery of a model drug Clindamycin Phosphate.


Keywords: Transfersomes, Acne vulgaris, Clindamycin Phosphate

Keywords: Transfersomes, Acne vulgaris, Clindamycin Phosphate

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Author Biographies

Neha Thakur, Nri Institute of Pharmacy, Bhopal, M.P., India

Nri Institute of Pharmacy, Bhopal, M.P., India

Prabhat Jain, Scan Research Laboratories, Bhopal, M.P., India

Scan Research Laboratories, Bhopal, M.P., India

Vivek Jain, Nri Institute of Pharmacy, Bhopal, M.P., India

Nri Institute of Pharmacy, Bhopal, M.P., India

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How to Cite
Thakur, N., Jain, P., & Jain, V. (2018). FORMULATION DEVELOPMENT AND EVALUATION OF TRANSFEROSOMAL GEL. Journal of Drug Delivery and Therapeutics, 8(5), 168-177. https://doi.org/10.22270/jddt.v8i5.1826