Evaluation of wound healing potential of methanolic Azadirachtaindica leaves extract in normal and diabetic rats
The present study was undertaken to evaluate the effect of Azadirachta indica leaves extract on wound healing activity in normal and streptozotocin-induced diabetic rats. Methanolic extract ointment was applied on excised wounds in healthy non diabetic and streptozotocin induced diabetic rats. This exhibited significant increase in mean percentage wound contraction and tensile strength in excision and dead Space wound models respectively, in both normal and diabetic rats when compared with control. The extract promoted wound contraction, reduced the wound closure time and induced proliferation of fibroblast as well as angiogenesis and re-epithelialization.
Keywords: Wound Healing, Azadirachta indica, Tensile strength, wound contraction
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