Evaluation of wound healing potential of methanolic Azadirachtaindica leaves extract in normal and diabetic rats

  • Amit Jain Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001
  • Sandeep Jain Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001
  • Murari Lal Soni Quality Assurance Laboratory, M.P. Council of Science and Technology, VigyanBhavan, Nehru Ngar, Bhopal (M.P.) 462003 India
  • Atul Kaushik Institute of professional studies, College of Pharmacy, Gwalior (M.P.) 474011 India

Abstract

The present study was undertaken to evaluate the effect of Azadirachta indica leaves extract on wound healing activity in normal and streptozotocin-induced diabetic rats. Methanolic extract ointment was applied on excised wounds in healthy non diabetic and streptozotocin induced diabetic rats. This exhibited significant increase in mean percentage wound contraction and tensile strength in excision and dead Space wound models respectively, in both normal and diabetic rats when compared with control. The extract promoted wound contraction, reduced the wound closure time and induced proliferation of fibroblast as well as angiogenesis and re-epithelialization.

Keywords: Wound Healing, Azadirachta indica, Tensile strength, wound contraction

Keywords: Wound Healing, Azadirachta indica, Tensile strength, wound contraction

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Author Biographies

Amit Jain, Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001

Asst Prof

Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001

Sandeep Jain, Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001

Asst Prof

Institute of Professional studies, college of Pharmacy Shivpuri Link Road Bela Ki Bawdi Gwalior (M.P.)474001

Murari Lal Soni, Quality Assurance Laboratory, M.P. Council of Science and Technology, VigyanBhavan, Nehru Ngar, Bhopal (M.P.) 462003 India

Technical Assistant

Quality Assurance Laboratory, M.P. Council of Science and Technology, VigyanBhavan, Nehru Ngar, Bhopal (M.P.) 462003 India

Atul Kaushik, Institute of professional studies, College of Pharmacy, Gwalior (M.P.) 474011 India

Principal

Institute of professional studies, College of Pharmacy, Gwalior (M.P.) 474011 India

References

1. Blakytny R, Jude E, The molecular biology of chronic wounds and delayed healing in diabetes, Diabetic Medicine, 2006, 23:594-608.
2. Pierce GF, Mustoe T, Pharmacologic enhancement of wound healing. Annual Review of Medicine, 1995, 46:467-481.
3. Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Allahabad: Lalit Mohan Basu; 1935.
4. Trease GE, Evans WC. A Textbook of Pharmacognosy. 7th ed. London: BailliereTindall; 1957.
5. Taranalli AD, Tipare SV, Kumar S, Torgal SS, Wound healing activity of Oxalis corniculata whole plant extract in rats, Indian Journal of Pharmaceutical Sciences, 2004, 66:444-446.
6. Shirwaikar A, Jahagirdar S, Udupa AL, Wound healing activity of Desmodium triquetrum leaves, Indian Journa of Pharmaceutical Sciences, 2003, 65:461-464.
7. Patil MB, Jalalpure JS, Ashraf A, Preliminary Phytochemical investigation and Wound Healing Activity of the leaves of Argemone maxicana Linn (Papaveraceae), Indian Drugs, 2001, 36:288-293.
8. Dissemond J, Goos M, Wagner SN, The role of oxidative stress in the pathogenesis and therapy of chronic wounds, Hautarzt, 2002, 53:718-723.
9. Arul V, Kartha R, Jayakumar R, A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices, Life Sciences, 2007, 80:275-284.
10. Philips GD, Whitehead RA and Kinghton DR: Initiation and pattern of angiogenesis in wound healing in the rat, The American Journal of Anatomy, 1991, 192:257-262.
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How to Cite
Jain, A., Jain, S., Soni, M., & Kaushik, A. (2018). Evaluation of wound healing potential of methanolic Azadirachtaindica leaves extract in normal and diabetic rats. Journal of Drug Delivery and Therapeutics, 8(4), 277-281. https://doi.org/10.22270/jddt.v8i4.1787