ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF SALIX AEGYPTIACA BARK EXTRACT ATTRIBUTE TO ITS ANTICANCER EFFICACY
Salix aegyptiaca has been used traditionally from the ancient time for its beneficial effects. The protective action of this plant is not well understood so far. Oxidative stress and inflammation are generally linked with carcinogenesis. In the present study, antioxidant, anti-inflammatory and anticancer activities of hydroethanolic bark extract of Salix aegyptiaca have been studied. The results of DPPH assay indicated the free radical scavenging ability of the bark extract (2-20 Âµg/ml). The inhibition of Ë™OH radical induced damage of pBR322 plasmid DNA by the extract (20 Âµg/ml) depicted its antioxidant property. This bark extract (5-800 Âµg/ml) exhibited the anti-inflammatory activity against heat induced protein denaturation. The medicinal property of S. aegyptiaca could be attributed to its free radicals scavenging ability and anti-inflammatory activity. Further, the extract (5-40 Âµg/ml) has shown anticancer activity against human hepatocellular carcinoma (HepG2) cells. However, the underlying mechanisms related to its anticancer effect need to be explored.
Keywords: Salix aegyptiaca, antioxidants, inflammation and hepatocellular carcinoma.
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