Study on Anti-inflammatory and Analgesic Effect of FangXiangTongLuo-cervical Plaster

  • Linfeng Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Ruomei Che Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Siqi Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Dandan Du
  • Dandan Han Department of Clinical Medicine, Hebei University, Baoding, China
  • Yutong Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Chen Liu Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Nan Hao Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Haonan Wu Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Shihui Sun Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Abstract

Objective: To study the anti-inflammatoryandanalgesic effects of FangXiangTongLuo-cervical Plaster. Methods: Preparation of FangXiangTongLuo cervical ointment. Using the model of the mouse ear swelling inflammation which is caused by xylene. The analgesic mode of hot-plate method and acetic acid wrinkle method, in order to study the anti - inflammatory and analgesic effects of FangXiangTongLuo-cervical Plaster. Result: The results showed that Fangxiangtongluo cervical plaster can effectively reduce the number of writhing in acetic acid-induced mice and increase the rate of writhing inhibition and analgesic percentage (p<0.01). In the hot plate experiment, Fangxiangtongluo cervical plaster can effectively improve the pain threshold of mice. With the increase in medication time, it can also significantly extend the time of the first mouse licking foot, thereby increasing the pain threshold of the mice. At the same time, Fangxiangtongluo cervical plaster can also significantly inhibit the degree of swelling of the mouse auricle caused by xylene, reducing the exudation of inflammatory substances in the body of mice. Conclusion: Fangxiangtongluo cervical plaster has significant anti-inflammatory and analgesic effects.

Keywords: FangXiangTongluo, cervical Plaster, anti-inflammation, analgesia

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Author Biographies

Linfeng Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Ruomei Che, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Siqi Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Dandan Han, Department of Clinical Medicine, Hebei University, Baoding, China

Department of Clinical Medicine, Hebei University, Baoding, China

Yutong Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Chen Liu, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Nan Hao, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Haonan Wu, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Shihui Sun, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China

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How to Cite
Li, L., Che, R., Li, S., Du, D., Han, D., Li, Y., Liu, C., Hao, N., Wu, H., & Sun, S. (2018). Study on Anti-inflammatory and Analgesic Effect of FangXiangTongLuo-cervical Plaster. Journal of Drug Delivery and Therapeutics, 8(4), 223-228. https://doi.org/10.22270/jddt.v8i4.1777