Study on the biological safety of TiO2 nanoparticles based on the oxidative stress pathway

  • Linfeng Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Siqi Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Lina Zhang Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Yuhui Ma Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Jingyi Yang Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Yufeng Yang Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Haonan Wu Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Lanlan Zhang Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Guowei Zhang Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Abstract

Objective: To study the effects of TiO2 nanoparticles in mice and explore the biological safety of TiO2 nanoparticles. Methods: The biological safety of TiO2 nanoparticles based on the oxidative stress pathway is investigated. One hundred mice were randomly divided into 10 groups. A low medium and high concentration experimental group and negative and positive control groups were investigated for both the intravenous injection and tracheal injection exposure experiments. Mice were observed for any symptoms, and the serum and lung homogenate for activity of SOD and content of MDA in serum and lung tissue were prepared. The scores of the allergic reaction determined the degree of anti-oxidation and the comprehensive experimental data determined the degree of injury in the mice. Results: An increase of TiO2 concentration in the nanomaterials led to a decrease of the content of MDA in serum and lung tissue of mice and the activity of SOD increased, indicating that mice showed oxidative stress in vivo. Conclusion: The strong direct exposure to a high concentration of TiO2 nanoparticles was harmful to the organism.1

Key words: Foundation medicine; TiO2; Nanoparticles; Oxidative stress; Biosafety nanomaterials

 

Keywords: Foundation medicine, TiO2, Nanoparticles, Oxidative stress, Biosafety nanomaterials

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Author Biographies

Linfeng Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Siqi Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Lina Zhang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Yuhui Ma, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Jingyi Yang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Yufeng Yang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Haonan Wu, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Lanlan Zhang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Guowei Zhang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China

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How to Cite
Li, L., Li, S., Zhang, L., Ma, Y., Yang, J., Yang, Y., Wu, H., Zhang, L., & Zhang, G. (2018). Study on the biological safety of TiO2 nanoparticles based on the oxidative stress pathway. Journal of Drug Delivery and Therapeutics, 8(3), 116-123. https://doi.org/10.22270/jddt.v8i3.1773