FORMULATION OPTIMIZATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ONDANSETRON HCL

  • Siraj N Shaikh Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • Band Afzal Abdul Razzak Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India
  • G. J. Khan Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Abstract

The aim of the work is to design Gastroretentive tablets of Ondansetron HCl for gastric retention by using 32 factorial designs. Floating tablets of Ondansetron HCl were prepared by direct compression method using polymers, sodium alginate and excipient. Gastroretentive tablets of Ondansetron HCl were successfully prepared by effervescent technique using different gel forming polymers- HPMC K200M, and sodium alginate. Formulation was optimized by design expert software. Floating tablets were evaluated for floating time, floating lag time, drug content, raft measurement and in vitro dissolution profile. The lag time is between 17-22 sec and floating time of the formulations for 12 hrs. The best fit model is Korsemeyer Peppas Model. From the study it is proof that the sustain release by floating tablets of Ondansetron HCl can be develop. Optimized batch selected was A3, The prepared gastroretentive test formulation was found to exhibit satisfactory physico-chemical characteristics at the end of 3 months, during the stability studies. The optimized formulation A3 was found to be stable at 400C/ 75% RH.

Keywords: Gastric retention time, Ondansetron HCl, HPMC, sodium alginate, measurement of raft, Factorial design, stability studies.

 

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Author Biographies

Siraj N Shaikh, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Band Afzal Abdul Razzak, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

G. J. Khan, Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India

References

1. Soni H, Ghulaxe C, Upadhyay S, Pillai S. Development and in vitro evaluation of an oral floating tablet of metronidazole. Journal of Drug Delivery and Therapeutics, 2018; 8(2): 83-86. doi:10.22270/jddt.v8i2.1673
2. Panda S, Sailada NS, Devi B, Pattnaik S, Maharana L, Design of Floating Drug Delivery Systems, Int. J. Pharm. Sci. Rev. Res,2016; 39(1):125-132.
3. Iftequar S, Saifee M, Swaroop L, Zaheer Z, Meraj S, Khan F et al, Formulation and evaluation of floating drug delivery system of ramipril Journal of Innovations in Pharmaceuticals and Biological Sciences JIPBS, 2013; 3(1):85-95.
4. Patle L, Formulation and Evaluation of Ondansetron Floating Tablet Research Journal of Pharmaceutical Dosage Form and Technology. 2017; 9(4):975-437.
5. Jha P, Prajapati V, Solanki H, Jani G, Kotak U pharmaceutical aspects of various floating drug delivery system world journal of pharmacy and pharmaceutical sciences 2015; 4(4)569-589.
6. Shraddha V, Suggala PV, Gholap S, Salunke R, Jain H, Swain K, review on: bilayer floating tablet world journal of pharmacy and pharmaceutical sciences. 2016; 5(02):1411-1423.
7. Kaur H, Loyee S, Garg R, Formulation and Evaluation of Gastroretentive Floating Drug Delivery System of Atenolol International Journal of Pharma Research and Health Sciences. 2016; 4(5):1371-1375.
8. Vennam S, Bhukya B, Formulation and Evaluation of Gastroretentive drug delivery system of Amlodipine Besylate Floating Tablets, Journal of drug delivery research.2014;3(1):11-21.
9. Gupta P, Gnanarajan, Kothiyal P, Floating Drug Delivery System A Review International Journal of Pharma Research, August 2015; 4(8):37-44
10. Agarwal D, Ranawat M, Chauhan C, Kamble R. Formulation and charecterisation of colon targeted ph dependent microspheres of capecitabine for colorectal cancer. Journal of Drug Delivery and Therapeutics, 2014; 3(6):215-222. doi:10.22270/jddt.v3i6.747
11. Soni H, Patel VA, Preparation and Evaluation of Raft Forming Chewable Tablet of Ranitidine Hydrochloride. International Journal of Pharmaceutical Research & Allied Sciences. 2016; 59(3):290-296.
12. Kumar S, Kumar A, Gupta V, Malodia K, Rakha P, Oral Extended Release Drug Delivery System: A Promising Approach Review Article, Asian Journal of Pharma Tech, April-June 2005; 2: 38-43.
13. Shaikh S, Khan GJ, Khurshid M, Ahmad S, Mohsin S, Salman S, “Floating with Bioadhesion: A Unique Expansion in GRDDS” A Review article, in AJPR, Dec 2015; 2:1-11.
14. Ratnaparkhi M. Formulation and development of floating drug delivery of Itopride Hcl. Journal of Drug Delivery and Therapeutics, 2013; 3(4):222-228. doi:10.22270/jddt.v3i4.579
15. Panesar S, Chaturvedi S, Saini N.K, Avasthi R, Quadri SS, Singh A, Current status of the ‘rule of halves’ of hypertension: a survey among the residents of slum resettlement colony from east Delhi, Health line, July-Dec 2013; 4:69-73.
16. Ramanathan. M, Subramanian. L, Manikandan. S, Venkatesan. N, Dr. Solairaj. P, Gastro retentive – floating drug delivery system an overview, Asian Journal of Pharmaceutical Research and Development.2017; 5 (4):1-07.
17. Kumar R, Gupta S, Chandra A, Gautam PK, Floating tablets: a realistic approach in gastroretentive drug delivery system. International journal pharmaceutical research and bio science. 2016; 5(6):1-20.
18. Kshirsagar SJ, Wadekar SB, Gastroretentive drug delivery system of hydrochlorothiazide: formulation, optimization and in vivo evaluation, Asian Journal of Pharmaceutical Sciences 2011; 6(3–4):166-175.
19. Panigrahy Rabi N, Mahale Arun N, Dhaked PS, Formulation And In Vitro Evaluation Of Combined Floating mucoadesive Tablet of Metoprolol Succinate, International Journal of Pharmacy and Pharmaceutical Science, 2011; 3,(2):221-226.
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How to Cite
Shaikh, S., Razzak, B. A., & Khan, G. J. (2018). FORMULATION OPTIMIZATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ONDANSETRON HCL. Journal of Drug Delivery and Therapeutics, 8(4), 185-195. https://doi.org/10.22270/jddt.v8i4.1763