IDENTIFICATION OF BIOLOGICAL COMPONENTS FROM POTENTIAL BONE HEALER MEDICINAL PLANTS
Nature has been a wellspring of therapeutic for a vast number of years and a great number of present day drugs have been separated from plant resources. It has been evaluated that natural prescriptions serve around 80% of the total population wellbeing requirement for many individuals throughout the world. Cissus quadrangularis a member of the family Vitaceae, Cardiospermum halicacabum and Dodonea viscosa members of the family Sapindaceae are well known for its utilization in the treatment of skin contaminations, blockage, piles, lack of health, weight loss, ant-inflammatory, anti-ulcer and bone crack healing. In the present study, based on GC-MS methanolic extract of stem and leaf of these three plants showed and identified fifteen major compounds with pharmacological activities. The FT-IR analysis showed similar functional groups of compounds related their medicinal properties such as Bone healing and wound healing activities.
Key words: C. quadrangularis, C. halicacabum, D. viscosa, GC-MS and FT-IR, Bone healing
 World Health Organization, General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine Switzerland: Geneva 2001
 Jaya C, Anuradha CV. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. Food and Chemical Toxicology, 2010, 48(8-9), 2021â€“2029.
 Vijayalakshmi A, Kumar P. R, Sakthi Priyadarsini S, Meenaxshi C. In Vitro Antioxidant and Anticancer Activity of Flavonoid Fraction from the Aerial Parts of Cissus quadrangularis L. against Human Breast Carcinoma Cell Lines. Journal of Chemistry, 2013, 1-9.
 Marquis G. Ramasamy B. Banwarilal S. Munusamy AP. Evaluation of antibacterial activity of plant mediated CaO nanoparticles using Cissus quadrangularis extract. Journal of Photochemistry and Photobiology B: Biology, 2016, 155(6), 28â€“33.
 Bhagath K, Muddannarao S, Gopalan K, Nampurath R, Mallikarjuna R, Chamallamudi C, Prasad K. Evidence-based assessment of anti-osteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. On ovariectomy-induced osteoporosis. Upsala Journal of Medical Science, 2009, 114(3), 140-148.
 Oben J, Kuate D, Agbor G, Momo C, Talla X. The use of a Cissus quadrangularis L. formulation in the management of weight loss and metabolic syndrome. Lipids in Health and Disease 2006, 5, 1-7.
 Arti BM, Talmale S, Kumar N, Gupta G, Reddanna P, Samar K, Das MB. Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and pro-inflammatory mediators. Journal of Ethnopharmacology, 2012, 141(3), 989â€“ 996.
 Banu J, Varela E, Ali N, Soomro R, Kazi N, Fernandes G. Inhibition of Bone Loss by Cissus quadrangularisin Mice: A Preliminary Report. Journal of Osteoporosis, 2012, 10
 Rajesh Kumar, Murugananthana G, Nandakumar K, Sahil Talwar. Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum. Phytomedicine. 2011, 18(2-3), 219â€“223.
 Sheeba MS, Asha VV. Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF- and iNOS expression, which is mediated by NF-B regulation, in RAW264.7 cells. Journal of Ethnopharmacology, 2009, 124 (1), 39â€“44.
 Waako BPJ, Gumede P,. Smith PI. The in vitro and in vivo anti-malarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. Journal of Ethnopharmacology, 2005, 99(1), 37â€“143.
 Huang MH, Huang SS,. Wang BS. Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo, Journal of Ethnopharmacology, 2011, 133(2), 743â€“750.
 J. Sadique T. Chandra V, Thenmozhi, Elango V. 1987) Biochemical modes of action of Cassia occidentalis and Cardiospermum halicacabum in inflammation. Journal of Ethnopharmacology, 1987, 19(2), 201â€“212.
 Jeyadevi R, Sivasudha T, Rameshkumar A, James Harnly M, Long Ze L. Phenolic profiling by UPLCâ€“MS/MS and hepato protective activity of Cardiospermum halicacabum against CCl4 induced liver injury in Wistar rats. Journal of Functional Foods, 2013, 5(1), 2 8 9 â€“2 9 8
 Albaker SM, Saeed Al gash FA, Hamid Hanash S, Ali A, Hazmi A. Prevalence and Evaluation of Antimicrobial Activity of Dodonaea viscosa Extract and Antibacterial Agents against salmonella Spp. Isolated from Poultry. International Journal of Medical and Health Sciences, 2015, 2(1), 901-908.
 Rashed K, Luo M, Zhang L, Zheng Y. Dodonaea viscosa (L.) extracts as anti-human immunodeficiency virus type-1 (HIV-1) agents and phyto constituents Peak, Journal of Medicinal Plant Research, 2013, 1(3), 19-25.
 Venkatesh S, Reddy YSR, Ramesh M, Swamy MM, Mahadevan N, Suresh B. Pharmacognostical studies on Dodonaea viscosa Leaves. African Journal of Pharmacy and Pharmacology, 2008, 2(4), 83-88.
 Teffo LS, Aderogba, Eloff JN. Antibacterial and antioxidant activities of four kaempferol methyl ethers isolated from Dodonaea viscosa Jacq. var. angustifolia leaf extracts. South African Journal of Botany, 2010, 76(1) 25-29.
 Duke JA. Database of Biologically Active Phytochemicals & Their Activity,1992, ISBN 9780849336713.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).