DEVELOPMENT AND EVALUATION OF GASTRO-RETENTIVE FLOATING BEADS OF DICYCLOVERINE HYDROCHLORIDE

  • Monika Setia Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
  • Kapil Kumar Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
  • Deepak Teotia Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Abstract

Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Dicycloverine is used for irritable bowel syndrome, abdominal pain, motion sickness and other conditions. Dicycloverine works by relieving smooth muscle spasms of the gastrointestinal tract. It is more soluble in water, alcohol and chloroform and slightly soluble in ether. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Dicycloverine could be achieved for increasing local action in the gastric region against irritable bowel disease (IBD) and GIT spasms with the development of sodium alginate floating beads containing Dicycloverine. Various formulations (FB1- FB7) of floating beads of Dicycloverine were developed using different concentrations of polymers like Ethyl cellulose, PVP, HPMC etc. The beads were prepared by Ionotropic gelation method using calcium chloride as a cross-linking agent. Floating beads were characterized by polymer compatibility by using FT-IR, DSC & Calibration. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content, and entrapment efficiency in vitro drug release and stability studies. Finally batch FB1 is concluded as optimum formulation.

Keywords: Dicycloverine, colon, IBD, gastric residence time, polymer mixture, ionotropic gelation.

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Author Biographies

Monika Setia, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Kapil Kumar, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Deepak Teotia, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

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How to Cite
Setia, M., Kumar, K., & Teotia, D. (2018). DEVELOPMENT AND EVALUATION OF GASTRO-RETENTIVE FLOATING BEADS OF DICYCLOVERINE HYDROCHLORIDE. Journal of Drug Delivery and Therapeutics, 8(4), 346-355. https://doi.org/10.22270/jddt.v8i4.1760