DEVELOPMENT AND EVALUATION OF GASTRO-RETENTIVE FLOATING BEADS OF DICYCLOVERINE HYDROCHLORIDE
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Dicycloverine is used for irritable bowel syndrome, abdominal pain, motion sickness and other conditions. Dicycloverine works by relieving smooth muscle spasms of the gastrointestinal tract. It is more soluble in water, alcohol and chloroform and slightly soluble in ether. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Dicycloverine could be achieved for increasing local action in the gastric region against irritable bowel disease (IBD) and GIT spasms with the development of sodium alginate floating beads containing Dicycloverine. Various formulations (FB1- FB7) of floating beads of Dicycloverine were developed using different concentrations of polymers like Ethyl cellulose, PVP, HPMC etc. The beads were prepared by Ionotropic gelation method using calcium chloride as a cross-linking agent. Floating beads were characterized by polymer compatibility by using FT-IR, DSC & Calibration. The prepared beads were evaluated for particle size, surface morphology, buoyancy, actual drug content, and entrapment efficiency in vitro drug release and stability studies. Finally batch FB1 is concluded as optimum formulation.
Keywords: Dicycloverine, colon, IBD, gastric residence time, polymer mixture, ionotropic gelation.
2. Chugh C, Nanda A, Gastroretentive drug delivery systems - A review. Int J pharma bio sci. 2017; 8(1): 62- 68.
3. Yerikala R, Pudi V, Saravanakumar K, Vadhireddy S. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach. Journal of Drug Delivery and Therapeutics, 2017; 7(4):110-119. doi:10.22270/jddt.v7i4.1473
4. Porwal A, Dwivedi H, Pathak K. Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy. Brazilian J Pharma Sci. 2017; 53(3):1-15.
5. Kumar K, Rai AK. Floating Microsphere: An innovative Approach for Gastro retention. J Pharmacy Research. 2012; 5(2):883-886.
6. Pund YP, Mundada AS., Design and Development of Sustained Release Floating Beads of Metronidazole Using Natural Polymer, SF Drug Deliv Res J. 2017; 1(1):1-9.
7. Kajale AD, Chandewar AV, Formulation and evaluation of oral floating beads of tramadol hydrochloride, Journal of Drug Delivery & Therapeutics. 2016; 6(4):7-16
8. Raysing S, Rangari S, Sonawane U, Bari S, Surana S, Formulation development and evaluation of novel dual-compartment capsule for stomach specific drug delivery. Journal of Drug Delivery and Therapeutics, 2017; 7(7):90-92. doi:10.22270/jddt.v7i7.1597
9. Kumar K, Pant NC, S Ahmad, MV Fateh, AK Rai, Bipin Verma, Himanshu Chaurasia. Development and evaluation of floating microspheres of curcumin in alloxan induced diabetic rats. Tropical Journal of Pharmaceutical Research. 2016; 15 (9): 1819-1825.
10. Kumari R, Verma N, Chaudhary N, Gastro Retentive Floating Microspheres a New Trend of Drug Delivery System, Int J Adv Research and Innovation. 2015; 3(2):459-467.
11. Ikechukwu UR, John Francis DE, Ambi AA. Development and evaluation of Ritonavir hollow microballoons for floating drug delivery. Univ J Pharm Res. 2017; 2(2): 30-34.
12. Kumar Arun B, Mahalakshmi K, Rao Maheshwara VU: Formulation and Evaluation of Gastro Retentive Floating Microbeads of Sumatriptan, Int J Life Sci and Review. 2015; 1 (4):137-143.
13. Kumar K, Rai AK. Development and evaluation of floating microspheres of herbal drugs. Tropical Journal of Pharmaceutical Research. 2012; 11(5), 713-719..
14. Ramesh Y, Balachandra P, Chinnaiah S. Formulation and Evaluation of Floating Microspheres of Norfloxacin, Res. J. Chem. Env Sci. 2013; 1(4):18-28.
15. Nayak AK, Pal D, Malakar J. Development, optimization, and evaluation of emulsion-gelled floating beads using natural polysaccharide-blend for controlled drug release, Polymer Eng & Sci. 2013; 53(2):238â€“250.
16. Felix Sunday Yusuf. Formulation and in-vitro evaluation of floating microballoons of stavudine. Univ J Pharm Res. 2016; 1(1): 13-19.
17. Arya LS, Kumar K, Padhy SK. Formulation and evaluation of floating microspheres of prazosin hydrochloride as a gastro retentive dosage form. International Journal of Research and Development in Pharmacy and Life Sciences. 2016; 5 (5): 2159-2165..
18. Neeta, Mehta Meenu, Satija Saurabh. Relevance of ionotropic gelation technique in the development of floating multiparticulate drug delivery systems. Int J Adv Sci Research. 2016; 1(4): 54-59.
19. Anyanwu NCJ, Adogo LY, Ajide B. Development and evaluation of in situ gelling gastroretentive
formulations of Meloxicam. Univ J Pharm Res. 2017; 2(3): 11-14.
20. Kapoor, D, Fabrication and characterization of non steroidal anti-inflammatory alginate beads for sustained release using natural polymer. Journal of Drug Delivery and Therapeutics, 2017; 7(2):77-80. doi:10.22270/jddt.v7i2.1401
21. Soni H, Ghulaxe C, Upadhyay S, Pillai S, Development and in vitro evaluation of an oral floating tablet of
metronidazole. J Drug Deliv Therap. 2018; 8(2):83-86.
22. Senthil Kumar, Jaykar B, Kavimani S. Formulation and evaluation of gastro-retentive floating drug delivery system of rabeprazole sodium, Int J Biopharma. 2011; 2(2):57-62.
23. Kumar K, Rai AK. Evaluation of anti-inflammatory and anti-arthritic activities of floating microspheres of herbal drug, International res j pharmacy. 2012; 3(1):186-19.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).