DEVELOPMENT OF A KIND OF FLAVORING TABLETS FOR CHILDREN'S USE

  • Chen Liu Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Haiyan Cao Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Linfeng Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Ruomei Che Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Zihui Li Department of Traditional Chinese Medicine, Hebei University, Baoding, China
  • Guowei Zhang Department of Traditional Chinese Medicine, Hebei University, Baoding, China

Abstract

Objective: In this study, based on children's medication preferences, Synsepalum dulcificum and Siraitia grosvenorii as raw material were used to develop a flavoring medicine for children.

Methods:  Synsepalum dulcificum and Siraitia grosvenorii as the raw material were applied to extract the Synsepalum dulcificum powder and Siraitia grosvenorii powder respectively, according to the orthogonal test design; the optimal proportion of flavoring powder was obtained. Low-substituted hydroxypropyl cellulose(L-HPC), polyvinylpolypyrrolidone(PVPP), sodium carboxymethyl starch(CMS-Na), microcrystalline cellulose(MCC) were taken, according to the orthogonal test design the optimum proportion of auxiliary materials, then the flavoring tablets was prepared according to the preparation process.

Results: Through orthogonal test design, the optimum ratio of Synsepalum dulcificum: Siraitia grosvenorii was 1:3, and mixing them up in proportion; the optimum ratio of L-HPC: PVPP: CMS-Na: MCC was 10: 8: 3: 6, and mix them up in proportion. Equal amounts of sugar and salt were obtained by mass ratio of 1 to 1. Mixing 1/3 amount of flavoring powder with 3/4 amount of auxiliary materials, using 20% ethanol as a wetting agent, using the remaining sugar as a filler, and granulating. After the granules were dried and whole grain, add the remaining auxiliary materials and magnesium stearate were added, then the flavoring tablets were prepared.

Conclusion: The effects of this formula were prominent, which could effectively intervene the taste of children's medicine; solve the practical problems concerning taking medications in children.

Keywords: Synsepalum dulcificum; Siraitia grosvenorii; drug use in children; flavoring tablets

 

Keywords: Synsepalum dulcificum, Siraitia grosvenorii, drug use in children, flavoring tablets

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Author Biographies

Chen Liu, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Haiyan Cao, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Linfeng Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Ruomei Che, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Zihui Li, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Guowei Zhang, Department of Traditional Chinese Medicine, Hebei University, Baoding, China
Department of Traditional Chinese Medicine, Hebei University, Baoding, China

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How to Cite
Liu, C., Cao, H., Li, L., Che, R., Li, Z., & Zhang, G. (2018). DEVELOPMENT OF A KIND OF FLAVORING TABLETS FOR CHILDREN’S USE. Journal of Drug Delivery and Therapeutics, 8(3), 14-19. https://doi.org/10.22270/jddt.v8i3.1755