ANTI-CANCER HERBLE DRUGS: AN OVERVIEW

  • Sonali R Pawar Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
  • Sampada S Jangam Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
  • Santosh A. Waghmare Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207

Abstract

"Cancer" is the term we give to a large group of diseases that vary in type and location but have one thing in common: abnormal cells growing out of control. It continues multiplying uncontrollably and the result of this accumulation of abnormal cells is a mass of cells called a "cancer". The Plant Kingdom produces naturally occurring secondary metabolites which are being investigated for their anticancer activities leading to the development of new clinical drugs. With the success of these compounds that have been developed into staple drugs for cancer treatment new technologies are emerging to develop the area further. New technologies include nanoparticles for Nano-medicines which aim to enhance anticancer activities of plant-derived drugs by controlling the release of the compound and investigating new methods for administration. This review discusses the demand for naturally-derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments. The purpose of this brief review is to assemble current literature on some herbal drugs and to focus on their beneficial roles and drug targets in cancer therapy and chemoprevention.

Keywords: 20 Herbal drugs, Cancer, Cell cycle

Downloads

Download data is not yet available.

Author Biographies

Sonali R Pawar, Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
Sampada S Jangam, Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
Santosh A. Waghmare, Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207
Department of Pharmaceutical Chemistry, JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra, India-412207

References

Anti-cancer drug: Journal of cancer science and research: https://www.omicsonline.org/scholarly/

Anticancer-drugs-journals-articles-ppts-list.php

Sisodiya PS, Plant Derived Anticancer Agents: A Review. International Journal of Research and Development in Pharmacy and Life Sciences, 2013; 2(2):293-208

Journal of Cancer Science and Research ISSN: 2576-1447: https://www.omicsonline.org/scholarly/anticancer-drugs-journals-articles-ppts-list.php

Greenwell M and Rahman P.K., Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Sciences and Research. 2015 Oct 1; 6(10):4103–4112.

Natural health news and discoveries: Top 20 Anti-Cancer Herbs and Plants: https://naturalon.com/top-20-anti-cancer-herbs-plants/view-all/

Huang S, Yang N, Liu Y, Gao J, Huang T, Hu L, et al. Grape seed proanthocyanidins inhibit colon cancer-induced angiogenesis through suppressing the expression of VEGF and Ang1. International journal of molecular medicine. 2012 Dec; 30(6):1410-1416

Ramakrishnan R. et al. Anticancer properties of zingiber officinale – ginger: a review: International Journal of Medicine and Pharmaceutical Sciences. Dec 2013; 3 (5):11-20

Zhao F, Wang L, Liu K et al.. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. Journal of Ethnopharmacology. 2009 Apr 21; 122(3):457-62.

Knott A, Reuschlein K, Mielke H et al. Natural Arctium lappa fruit extract improves the clinical signs of aging skin. Journal of cosmetic dermatology. 2008 Dec; 7(4):281-9.

Lin SC, et al. Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. Journal of biomedical science. 2002 Sep-Oct; 9(5):401-9.

Bryson PD, Watanabe AS, Rumack BH, Murphy RC et al. Burdock root tea poisoning. Case report involving a commercial preparation. Journal of the American Medical Association. 1978 May 19; 239(20):2157.

Tamayo C et al. The chemistry and biological activity of herbs used in Flor-essence herbal tonic and Essiac. Phytotherapy Reserach. 2000; 14(2):1-14.

Rodriguez P, Blanco J, Juste S. et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis.1995 Aug; 33(2):134-5.

Sasaki Y, Kimura Y, Tsunoda T, Tagami H et al. Anaphylaxis due to burdock. International journal of dermatology. 2003 Jun; 42(6):472-3.

Chan YS, Cheng LN, Wu JH, et al. A review of the pharmacological effects of Arctium lappa (burdock). Journal of Inflammopharmacology. 2011 Oct; 19(5):245-54.

Cancer and the cell cycle: https://www.khanacademy.org/science/biology/cellular-molecular-biology/stem-cells-and-cancer/a/cancer

Cell cycle in cancer: http://www.cyclacel.com/research_science_cell-cycle.shtml

Heyman J, Lieven D et al. Molecular plant. Cell press science direct. 2012, 5(6):1182-1194

Cell cycle in cancer: http://www.cyclacel.com/research_science_cell-cycle.shtml

Elham S, Siamak S, Behzad B. et al. Herbal Medicine as Inducers of Apoptosis in Cancer Treatment. Advanced Pharmaceutical Bullets, 2014, 4( 1):421-427

Agarwal N , Majee C. , Chakraborthy G. S. et al. Natural Herbs as Anticancer Drugs. International Journal of PharmTech Research. July-Sept 2012; 4 (3):1142-1153

Desai A G, Qazi G N, Ganju R K et al. Medicinal Plants and Cancer Chemoprevention. Current Drug Metabolism published by national institute of health. 2008 Sep ; 9(7):581–591

American Cancer Society. Cancer facts & figures 2016. Atlanta, GA: American Cancer Society; 2016.

Siegel RL, Miller KD, Jemal A et al. Cancer statistics, 2016. CA Cancer J Clin. 2016; 66(1):7-30.

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RG, Barzi A, et al. Colorectal cancer statistics, 2017. A Cancer Journal of Clinicians 2017; 67(3):177-93.

Javed I , Banzeer A , Tariq M. et al. Plant-derived anticancer agents: A green anticancer approach. Asian Pacific Journal of Tropical Biomedicine. 2017; 7(12):1129–1150

Traditional Medicinal Plants for anticancer activity: https://www.researchgate.net/publication/258935441

Lim, Shuhui and Kaldis, Philipp. et. al. Cdks, cyclins and CKIs: Roles beyond cell cycle regulation. Development. 2013; 140(15):3079-93

Masui, Y. (2001). From oocyte maturation to the in vitro cell cycle: the history of discoveries of Maturation-Promoting Factor (MPF) and Cytostatic Factor (CSF). Differentiation 2001 Dec; 69(1):1-17.

Asperheim, M.K., Pharmacology: An Introductory Text. 9 ed, ed. R. Carter and L. Henderson. 2002, Philadelphia: WB Saunders Co. 97

Maram S, Mahmoud M, Zakaria A. Anticancer activity of Aloe vera and Calligonum comosumextracts separetely on hepatocellular carcinoma cells. Asian Pacific Journal of Tropical Biomedicine. May 2015; 5(5):375-381

Garrett s. et al. Anticancer properties of research-grade hydrastis canadensis (goldenseal) and characterization of its effect on the mdr1-encoded phosphoglycoprotein efflux pump (2009) all theses. 645. https://tigerprints.clemson.edu/all_theses/645

Brian S, Anna M. R, Sharon G. et al. Anti-cancer effects of aloe-emodin: A systematic review. Journal of Clinical and Translational Research.2017; 3(4):1-14

CDK. (2014). In Scitable. Retrieved from http://www.nature.com/scitable/topicpage/cdk-14046166.

CDK-activating kinase. (2015, August 5). Retrieved October 13, 2015 from Wikipedia: https://

en.wikipedia.org/wiki/CDK-activating_kinase.

Cancer biology: bio1220.biology.gatech.edu/?page_id=69

Cooper, G. M. (2000). The events of M phase. In The cell: A molecular approach (2nd ed.). Sunderland, MA: Sinauer Associates. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK9958/.

Cyclin. (2015, July 29). Retrieved October 13, 2015 from Wikipedia: https://en.wikipedia.org/wiki/Cyclin.

Cyclin-dependent kinase. (2015, September 14). Retrieved October 13, 2015 from Wikipedia: https://en.wikipedia.org/wiki/Cyclin-dependent_kinase.

Cyclin-dependent kinase inhibitor protein. (2014, February 4). Retrieved October 13, 2015 from Wikipedia: https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_inhibitor_protein.

Haizhou L, Schmitz J, et al. Clove Extract Inhibits Tumor Growth and Promotes Cell Cycle Arrest and Apoptosis. Oncology research. 2014; 21(5):247–259.

Miraj. Anti-cancer and anti-tumor activity of Glycyrrhiza uralensis Fisch Sepid. Der Pharmacia Letter, 2016; 8(19):417-420

Jorge F.S., Ferreira D L. Luthria et al. Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer. Molecules. 2010; 15(5):3135-3170

Pamela O, Saleem A, Jose-Antonio G et al. Dandelion root extracts affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways. Oncotarget. 2016 Nov 8; 7(45):73080–73100

P53 (disambiguation). Retrieved October 13, 2015 from Wikipedia: https://en.wikipedia.org/wiki/P53.

Chu XT, de la C J, Hwang SG, Hong H et al. Asian Pacific Journal of Cancer. 2014; 15(12)0:4809-13.

The_Apha_Practical_Guide_to_Natural_Medi

Cancer_The_Complete_Recovery_Guide

Gurel E, Karvar S, Yucesan B, Eker.et al. An Overview of Cardenolides in Digitalis - More Than a Cardiotonic Compound. Current Pharmaceutical Design. 2017;23(34):5104-5114

Phillipson JD et al. Medicinal Plants. Journal of Biological Education (Society of Biology). 1999; 31(2):109

Sahpazidou D, Geromichalos GD, et al. Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells. Toxicology Letters. 2014; 230:218–224.

Greenwell M. and Rahman P et al. Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Science and Research. 2015; 6(10):4103–4112

Salomi MJ, Nair SC, Panikkar PR et al. Inhibitory effects of Nigela sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutrition and Cancer. 1991; 16:67–72.

Abdullaev FI, Espinosa-Aguirre JJ et al. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer detection and prevention. 2004; 28:426–32.

Abdullaev FI et al. Biological effects of saffron. BioFactors. 1993; 4:83–6.

Guanabana Anticancer Effects and Research Findings: http://www.superfoods-scientific-research.com/ medicinal-herbs/guanabana-anticancer-effects.html

Numerous Anti-Cancer and Protective Effects of Milk Thistle Extract (Silymarin): https://integrativeoncology-essentials.com/2013/01/read-about-the-numerous-anti-cancer-and-protective-effects-of-milk-thistle-extract-silymarin/

Published
2018-07-14
How to Cite
1.
Pawar SR, Jangam SS, Waghmare SA. ANTI-CANCER HERBLE DRUGS: AN OVERVIEW. JDDT [Internet]. 14Jul.2018 [cited 8Sep.2024];8(4):48-. Available from: http://jddtonline.info/index.php/jddt/article/view/1749