LAXATIVE ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF PUTRANJIVA ROXBURGHII.

  • Shivansh Yadav SPS, IFTM University, Moradabad 244002, U.P. India
  • Prevesh Kumar SPS, IFTM University, Moradabad 244002, U.P. India
  • Bhawna Shridhar SPS, IFTM University, Moradabad 244002, U.P. India
  • Divaker Shukla SPS, IFTM University, Moradabad 244002, U.P. India
  • Ved Pal Baiga SPS, IFTM University, Moradabad 244002, U.P. India
  • Munesh Mani SPS, IFTM University, Moradabad 244002, U.P. India

Abstract

Background: This study was aimed to assess the possible laxative effect of roxburghii hydroalcoholic leaves extract of Putranjiva in albino’s Wistar rats.

Method: Rats were divided in 5 groups of 6 animals each, I group served as control, II group as standard (sodium picosulfate) while group III, IV and V were treated with leaves extract of Putranjiva roxburghii at doses of 250, 500 and 750 mg/kg respectively. The statistical analysis of results were carried out using and one-way analysis (ANOVA) followed by Student t-test.

Result and Discussion: The laxative activity was determined based on the weight of the faeces matter. The effects of the hydroalcoholic leaves extract of Putranjiva roxburghii and reference also evaluated. The hydroalcoholic leaves extract of Putranjiva roxburghii administered orally at three different doses produced significant laxative activity and reduced loperamide induced constipation in dose dependent manner. The effect of the extract at 500 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o).

Conclusion: The results showed that hydroalcoholic leaves extract of Putranjiva roxburghii has a significant laxative activity.

Keywords: Laxative, Loperamide, Constipation.

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Author Biographies

Shivansh Yadav, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

Prevesh Kumar, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

Bhawna Shridhar, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

Divaker Shukla, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

Ved Pal Baiga, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

Munesh Mani, SPS, IFTM University, Moradabad 244002, U.P. India

SPS, IFTM University, Moradabad 244002, U.P. India

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How to Cite
Yadav, S., Kumar, P., Shridhar, B., Shukla, D., Baiga, V., & Mani, M. (2018). LAXATIVE ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF PUTRANJIVA ROXBURGHII. Journal of Drug Delivery and Therapeutics, 8(4), 142-144. https://doi.org/10.22270/jddt.v8i4.1741