EVALUATION OF CYTOPROTECTIVE EFFICACY OF ARISAEMA LESCHNAULTII BLUME AGAINST CYCLOPHOSPHAMIDE INDUCED HEPATOTOXICITY IN TUMOR BEARING MICE
Cyclophosphamide (CP) is a widely used antineoplastic drug, it is used for the treatment of several malignancies. However, upon treatment, it induces severe toxicity due to its oxidative stress capabilityÂ In this study we evaluate the cytoprtective efficacy of Arisaema leschnaultii blume (AL) against cyclophosphamide induced hepatotoxicity in tumor bearing mice due to its antioxidant property. Female Swiss albino mice were used. Group I-Naive control, Group II-DAL bearing, Group III-DAL + CP, Group IV-Â DAL + AL + CP,Â Group V- DAL + AL + CP, Group VI-DAL + Amifostine + CP. CP induced hepatic damage as indicated by significant elevation (P < 0.05) in aspartate aminotransferase, organ weight, and evidence by the histological study. CP also induced hepatic oxidative stress as indicated by significant elevation (P < 0.05) in malondialdehyde content, hydrogen peroxide (H2 O2 ) generation, nitrite level, and the level of glutathione (GSH) peroxidase crashed in the CP treated group. AL enhanced the antioxidant defense system as indicated by elevation in GSH level, catalase activity, and GSHâ€‘Sâ€‘transferase activity and by inhibiting MDA.
Keywords: hepatotoxicity, glutathione, antioxidants, cytoprotective etc.
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