FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF GLICLAZIDE HYDROCHLORIDE
This article illustrates the Formulation and Characterization of Mucoadhesive microspheres of Gliclazide Hydrochloride.The mucoadhesive microspheres were prepared by the Emulsion Solvent Evaporation method by using Eudragit L 100 and Ethyl Cellulose 22 CPS polymers & PEG 4000 added as a pore forming agent . Formulated microspheres were evaluated for various parameters. The characteristics like shape and structure of prepared microspheres were determined by Optical microscopy and scanning electron microscopy respectively. The prepared microspheres exhibited prolonged drug release (12 hrs) the mean particle size increased as the concentration of Eudragit L 100 increased. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. The optimized formulation shows following cumulative release after 12 hrs i.e. 96.40%. The microspheres exhibited 80% mucoadhesion and showed good drug entrapment efficiency i.e. 80.13Â±0.91% as well as drug loading efficiency is 26.70Â±0.75%. Â It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Gliclazide Hydrochloride in the sustained release manner for management of Type II Diabetes Mellitus.
Keywords: Mucoadhesive, Gliclazide Hydrochloride, Microspheres, Eudragit L 100, drug entrapment efficiency.
2) Hu X, Zhang J, Tang X, Li M, Ma S, Liu C, Gao Y, Zhang Y et al. An Accelerated Release Method of Risperidone Loaded PLGA Microspheres with Good IVIVC: Research Article. Current Drug Delivery. 2018; (15):87-96.
3) Kumar S, Anusha G, Rajyalaxmi, Srinivas and Manoj. Design and Evaluation of A Controlled Release Drug Delivery System For Management of Rheumatism: Research Article. Journal of Pharmacovigilance. 2017; (5):6-17.
4) Verma V, Patel MM. Formulation and Evaluation of Mucoadhesive Microspheres Of Antihypertensive Drug, World Journal of Pharmacy and Pharmaceutical Sciences, 2017; (6):929-950.
5) Kumar S, Nanda A. Formulation Optimization and In-Vitro Evaluation of Gastroretentive Mucoadhesive Microspheres of Furosemide: Research Article. International Journal of Pharmacy and Pharmaceutical Sciences. 2016; (8):392-398.
6) Shanthi Priya CH. Design and Characterization of Mucoadhesive Microspheres for Gastro-Retentive Delivery of Famotidine Hydrochloride: Research Article. Bioengineering & Biomedical Science. 2015; (5):1-6.
7) Gada S, Yeganoor AK. Formulation and Evaluation of Glipizide Mucoadhesive Microspheres: International Journal of Pharma Research and Health Sciences. December 2016; (4):1483-1488.
8) Agarwal D, Ranawat M, Chauhan C, Kamble R. Formulation and charecterisation of colon targeted ph dependent microspheres of capecitabine for colorectal cancer. Journal of Drug Delivery and Therapeutics, 2014; 3(6):215-222. doi:10.22270/jddt.v3i6.747
9) Shaikh S, Khan G J, Shaikh S, Fakir H, Shaikh S And Shaikh M F. Microspheres As A Multiparticulate Drug Delivery System: A Review. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; (5):274-292.
10) Shaikh TA, Shinkar DM, Saudagar RB, Review: Polymers Used in the Mucoadhesive Drug Delivery System , International Journal of Pharma Research & Review, May 2016; 5(5):45-53
11) Sivasankar Mohanty And Gottumukkala Krishna Mohan. Formulation And In-Vitro Evaluation Of Glipizide Loaded Microspheres Prepared With Pectin Extracted From Dillenia Indica & Abelmoschus Esculentus, Research Article. International Journal of Pharma and Bio Sciences. July 2015; (6):498-505.
12) Reddy DV, Navaneetha K. Comparative Assessment of Potential of Various Polymers in the Formulation Development and Evaluation of Mucoadhesive Microspheres of Glipizide: Research Article. Journal of Global Trends in Pharmaceutical Sciences. 2015; (6):2379-2387.
13) Rouf MA Mamun A, Bagchi M, Amin ML, Sutradhar BK, Huda NH. Development Of Natural Gum Based Glipizide Mucoadhesive Microsphere: Research Article. Journal of Applied Pharmaceutical Science. Jan 2014; (4):066-069.
14) Sharma HK, Lahkar S, Nath LK. Formulation And In Vitro Evaluation Of Metformin Hydrochloride Loaded Microspheres Prepared With Polysaccharide Extracted From Natural Sources: Research Article. Acta Pharm, January 2013: (63):209â€“222.
15) Sarfaraz Md, Venubabu.P, Doddayya Hiremath and Prakash SG. Mucoadhesive Dosage Form of Glibenclamide. Design And Characterisation: Research Article. Ijpbs. Apr-Jun 2012; (2):162-172.
16) Shailendrasingh V, Thakur A, Mazahar Farooqui B and S D Naikwade. Thermodynamic Studies Of Transition Metal Complexes With Metformin Hydrochloride Drug In 20 % (V/V) Ethanol-Water Mixture: Research Article, Pelagia Research Library. 2012; (3):1406-1409.
17) Senthil A, Raja BD, Sureshkumar P, Thakkar HR, Sivakumar T. Chitosan Loaded Mucoadhesive Microspheres Of Glipizide For Treatment Of Type 2 Diabetes Mellitus In Vitro And In Vivo Evaluation: Research Article. Scholars Research Library. 2011; (3):366-379.
18) Hardenia SS, Jain A, Patel R, Kaushal A. Formulation and Evaluation Of Mucoadhesive Microspheres Of Ciprofloxacin: Research Article. Journal of Advanced Pharmacy Education & Research. 2011; (4):214-224.
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