• Ashish Jain School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India
  • Harish C Ahirwar Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
  • Shivam Tayal Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
  • Pradeep K. Mohanty School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India


Fast-dissolving oral films have emerged as alternative dosage forms for the patients who experience difficulties in swallowing traditional oral solid dosage forms such as tablets, capsules, and syrups etc.   These dosage forms disintegrate or dissolve very quickly within seconds when placed in the mouth cavity without need of water or chewing. Due to fast dissolution it provide faster onset of action, bypassing the first pass metabolism, reducing gastric degradation and metabolism of drugs and thus enhance their oral bioavailability. These properties of oral films with patient convenience and compliance made popular and accepted dosage form for pediatric and geriatric as well as adult population. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders, epilepsy and many more diseases. The present review provides up to date review in fast dissolving oral films in tabular form so researches can easily track various technologies/research in design and development of oral fast dissolving film.

Keywords: Mouth dissolving films, Oral dispersible film, Oral dissolving film, Oral disintegrating film.


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Author Biographies

Ashish Jain, School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India
School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India
Harish C Ahirwar, Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
Shivam Tayal, Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
Sagar Institute of Pharmacy and Technology, Bhopal, M.P., India
Pradeep K. Mohanty, School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India
School of Pharmacy, LNCT University, Kolar Road, Bhopal, M.P., India


1. Liang CA, Chen HL. Fast dissolving intraoral drug delivery systems. Expert Opin. Ther. Patents. 2001; 11(6):981-986.
2. Ehtezazi T, Algellay M, Islam Y, Roberts M, Dempster NM, Sarker SD The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films. J Pharm. Sci 2018, 107(4):1076–1085
3. Habib W, Pritchard JF, Bozigian HP, Gooding AE, Griffin RH, Mitchell R, Bjurstrom T, Panella TL, Huang AT, Hansen LA. Fast-dissolve drug delivery system. Crit. Rev. Ther. Drug Carrier Syst. 2000; 17:61–72.
4. Siddiqui MD, Garg G, Sharma PA. Short review on: A novel approach in oral fast dissolving drug delivery system and their patents. Adv. Bio. Res. 2011; 5(6):291-303.
5. Brniak W, Jachowicz R, Pelka Przemyslaw. The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets. Saudi Pharm. J. 2015; 23:437-443.
6. Gisel EG. Oral motor skills following sensorimotor intervention the moderately eating impaired child with cerebral palsy. Dysphagia. 1994; 9:180–192.
7. Avery SW, Dellarosa DM. Approaches to treating dysphagia patients with brain injury. Am. J. Occup. Ther. 1994; 48(3):235–239.
8. Chauhan NS, Tomar A, Sharma K, Mittal A, Bajaj U. Formulation and evaluation of fast dissolving oral film of dicyclomine as potential route of buccal delivery. Int. J. Drug Dev. Res.2012; 4 (2):408-417.
9. Patel A, Shaikh S, Khan G J, Molvi KI, Patel H. Review Article: various aspects of oral fast disintegrating dosage form. Int. J. Pharmacy Pharm. Res. 2016; 6(4):689-701.
10. Dixit RP, Puthli SP.Oral strip technology: Overview and future potential. J. Control. Release.2009; 139(2):94-107.
11. Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. Int. J. Chem Tech. Res. 2010; 2(1):576-583.
12. Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: Innovations in formulation and technology. Int. J. Pharm. Sci. Rev. Res. 2011; 9(2):50–57.
13. Bala R, pravin pawar, sushil khanna, sandeep arora.Orally dissolving strips: A new approach to oral drug delivery system. Int. J. Pharm. Invest. 2013; 3(2):67–76.
14. Choudhary DR, Patel VA, Chhalotiya UK, Patel HV, Kundawala AJ. Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine. Sci. Pharm. 2012; 80:779–787.
15. Zhang H, Zhang J, Streisand JB. Oral mucosal drug delivery: clinical pharmacokinetics and therapeutic applications. Clin. Pharmacokinetic. 2002; 41(9):661‐680.
16. Jangra PK, Sharma S, Bala R.Fast dissolving oral films: Novel way for oral drug delivery. Int. J. Uni. Pharm. Bio. Sci. 2014; 3(1):6-27.
17. Heer D, Aggarwal G, Kumar SLH. Recent trends of fast dissolving drug delivery system-An overview of formulation technology. Pharmacophore. 2013; 4(1):1-9.
18. Mahajan A, Chhabra N, Aggarwal G. Formulation and Characterization of Fast Dissolving Buccal Films: A Review. Der Pharm Lett. 2011; 3(1):152-165.
19. Rathi V, Senthil V, Kammili L, Hans R. A brief review on oral film technology. Int. J. Res. Ayur. Pharm. 2011; 2:1138-1147.
20. Kulkarni AS, Deokule HA. Exploration of different polymers for use in the formulation of oral fast dissolving strips. J. Current Pharm. Res. 2010; 2(1):33-35.
21. Patel A, Prajapati DS, Raval JA. Fast dissolving films: as a newer venture in fast dissolving dosage forms. Int. J. Drug Dev. Res.2010; 2:232-246.
22. Kalyan S, Bansal M. Recent trends In the development of oral dissolving film. Int. J. Pharmtech Res. 2012; 4:725-733.
23. Patil D, Ahmed AH, Awais M, Akhtar S, Bairagi V. Design and development of fast dissolving film of telmisartan. Pharma Science Monitor. 2018; 9(1):171-187.
24. Song Q, Shen C, Shen, B, Lian W, Dai B, Yuan H. Development of a fast dissolving sublingual film containing meloxicam nanocrystals for enhanced dissolution and earlier absorption. Colloids and Surfaces B: Biointerfaces. 2018; 163(1): 9-18.
25. Kadam V. S., Bharkad V. B., Shete G. A., Jameel A, Shendarkar G. R., and Jadhav S. V. Formulation and evaluation of fast dissolving oral film of metoclopramide hcl. World journal of pharmacy and pharmaceutical sciences. 2017; 6(8):2052-2066.
26. Bajpai S. K., Shah FF, Bajpai M, Jadaun M, Jyotish P. Dynamic release of Amoxicillin from Orally Dissolving Film (ODF) composed of Casein and Sodium alginate. J Drug Res Dev. 2017; 3(2): doi
27. Patil JS, Deokar AB, Vilegave KV, Morani DO,Dhadde SB. Design, evaluation and characterization of rapidly dissolving oral strips of metoprolol succinate. J. Pharm. Analy. Insights.2016; 1(2):1-6.
28. Reddy S, Devi S, Naik V, Mounica NVN, Rao AA. Formulation and evaluation of fast dissolving buccal films conaining zolmitriptan. Int.J.Pharm. chem.Res. 2016; 1(1):129-140.
29. Newton AMJ, Rani SM, Sukhjinder K. Fabrication and evaluation of fast disintegrating oral hybrid films of propranolol hydrochloride by using pectin and synthetic polymers. J. Dev.Drugs.2016;5(2):157
30. Nair SS, Padamanabhan R, Sreena K.Development and Evaluation of fast dissolving oral thin film containing prochlorperazine maleate. Eur. J. Pharm. Medical Res. 2016; 3(1):379-384.
31. Pathan A, Gupta MK, Jain NK, Dubey A, Agarwal A. Formulation and evaluation of fast dissolving oral film of promethazine hydrochloride using different surfactant. J. Innov. Pharm. Bio.Sci.2016; 3(1):74-84.
32. Soni MM, Patel KR. Formulation and evaluation of fast dissolving film of lurasidone Hcl. Int. J. Pharm. Res. Bio.Sci.2016; 5(2):101-123.
33. Haque SE, Sheela A. Development of polymer-bound fast-dissolving metformin buccal film with disintegrants. Int. J. Nanomedicine.2015; 10(1):199-205.
34. Thakur S, Raju L, Soni A, Agnihotri B. Formulation and evaluation of fast dissolving film of losartan potassium.World J. Pharmcol. Res. Tech.2015; 3(6):179-189.
35. Rekha MS, Sultana SKS, Mahathi K, Parveen P, Prathima B, Devi AS. Formulation and evaluation of fast dissolving buccal film containing isradipine solid dispersion. Amer. J. Pharmtech. Res.2015; 5(2):221-247.
36. Pawar SV, Junagade MS. Formulation and evaluation of mouth dissolving film of risperidone. Int. J. PharmTech. Res.2015; 8(6):218-230.
37. Jelvehgaril M, Montazam SH, Soltani S,Mohammadi R, Azar K,Montazam SA. Fast dissolving oral thin film drug delivery systems consist of ergotamine tartrate and caffeine anhydrous.Pharm.Sci.2015; 21:102-110.
38. Goutam K, Garg R, Sharma A, Singh A,Sharma P, Kaushal S. Formulation and evaluation of oral fast dissolving films of promethazine theoclate . Indo. Ameri.J.Pharm.Res.2015; 5(8):2536-2544.
39. Mundada AS, Jain RA. Formulation, development and optimization of fast dissolving oral film of montelukast sodium. Int. J. Drug Dev. Res.2015; 7(4):40-46.
40. Dwivedy BN, Dabral P, Kumar R. Preparation and evaluation of mouth dissolving film of pantoprazole sodium. World J. Pharm. Pharmceut. Sci.2014; 3(8):1564-1576.
41. Kumar R, Pandey GS, Sharma R, Singh Y, Teotia UVS. Effects of maltodextrin and glycerin on mechanical properties of oral fast dissolving film of salbutamol sulphate. Int. J. Adv. Pharm. Bio. Chem. 2014; 3(1):199-209.
42. Prabhu P, Dubey A, kamath K. formulation and Evaluation of fast-dissolving films of lisinopril. Egyp. Pharm. J.2015; 14:56-64.
43. Swamy NGN, Kumar SS. Formulation and evaluation of fast dissolving oral films of palonosetron hydrochloride using Hpmc-E5.Int.J. Pharm. Chem. Sci.2014; 3(1):145-150.
44. Pandey P, Chauhan S.Fast dissolving sublingual films of zolmitriptan : A novel approach for migraine attacks.Ind.J.Pharm. Edu. Res.2014; 48(1):67-72.
45. Deepthi A, Reddy V, Navaneetha K. Formulation and evaluation of fast dissolving oral films of zolmitriptan. Ameri. J. Adv. Drug Deliv.2014; 2(2):153-163.
46. Kumar SK, Nagabhushanam MV, Sambasiva Rao KRS, Bhikshapathi DVRN. Formulation development and in vivo evaluation of zolmitriptan oral dissolving films.Int.J.Pharm.Bio.Sci.2013; 4(3):638-654.
47. Patel HJ, Patel PB,Kamdar KM, Patel KB,Shah AA, Patel ZP. Development and optimization of fast dissolving film of losartan potassium. Amer. J. Pharm. Health Res.2013; 1(2):35-44.
48. Kathpalia H, Sule B, Gupte A. Development and Evaluation of Orally Disintegrating Film of Tramadol Hydrochloride. Asian Journal of biomedical and pharmaceutical sciences. 2013; 3(24):27-32.
49. Bansal G, Garg V, Siddiqui MD. Investigation of polymers alone and in combination for the development of oral thin film. Int.J.Inv.Pharm.Sci. 2013; 1(3):31-235.
50. Nalluri Buchi N., Sravani B., Maheswari K.M., Srianusha Sai V., Bramhini. R. Sri. Development and evaluation of mouth dissolving films of salbutamol sulfate. Journal of Chemical and Pharmaceutical Research. 2013; 5(3):53-60.
51. Panchal Mital S., Patel Hiren, Bagada Aarti, Dr. Vadalia K.R. Formulation and Evaluation of Mouth Dissolving Film of Ropinirole Hydrochloride by Using Pullulan Polymers. International Journal of Pharmaceutical Research & Allied Sciences. (2012); 1(3):60-72.
52. Choudhary DR, Patel V, Patel H. Exploration of film forming properties of film formers used in the formulation of rapid dissolving films. International Journal of Chem Tech Research. 2011; 3(2):531-533.
53. Mishra R, Amin A. Formulation and Characterization of Rapidly Dissolving Films of Cetirizine hydrochloride using Pullulan as a Film Forming Agent. Indian Journal of Pharmaceutical Education and Research. 2011; 45(1):71-77.
54. Saini S, Nanda A., Dhari J. Formulation, Development & Evaluation of Oral Fast Dissolving Anti-Allergic Film of Levo cetrizine Dihydrochloride. J. Pharm. Sci. & Res. 2011; 3(7):1322-1325.
55. Samta, Saini S, Rana A.C., Gupta S. Optimization of formulation of fast dissolving films made of pullulan polymer. International Journal of Pharmaceutical Sciences Review and Research. 2011; 9(1):127-132.
56. Choudhary DR, Patel VA, Patel HV, Kundawalal AJ. Formulation and evaluation of quick dissolving film of levocetirizine dihydrochloride. International Journal of Pharmacy & Technology. 2011; 3(1):1740-1749.
57. Mishra R, Amin A. Design and development of rapidly dissolving films using ion exchange resin for taste masking. International Journal of Drug Formulation & Research. 2011; 2(2):314-343.
58. Raju S., Reddy P. Sandeep, V. Anirudh Kumar, A. Deepthi, K. Sreeramulu Reddy, P.V. Madhava Reddy. Flash release oral films of metoclopramide hydrochloride for pediatric use:Formulation and in-vitro evaluation. J. Chem. Pharm. Res. 2011; 3(4):636-646.
59. Patil AK, GhorwadeVK, Patil S, Ikkurthi K, Inuganti KS, Porandla V. Formulation and evaluation of Montelukast sodium fast dissolving films by using Gelatin as a film base. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2011; 2(3):880-887.
60. Choudhary DR, Patel Vishnu A, Chhalotiya Usmangani K., Patel Harsha V, Kundawala Aliasgar J. Formulation and Evaluation of Fast Dissolving Film of Levocetirizine Dihydrochloride Using Different Grades of Methocel. Journal of Pharmacy Research. 2011; 4(9):2919-2924.
61. Mane M.S., Kulkarni A. S., Deokule H.A., Ghadge D. M. Exploration of different polymers for use in the formulation of oral fast dissolving strips. Journal of current pharmaceutical research. 2010; 2(1):33-35.
62. Murata Y, Isobe T, Kofuji K, Norihisa N. Preparation of Fast Dissolving Films for Oral Dosage from Natural Polysaccharides. Materials. 2010; 3:4291-4299.
63. Chen MJ, Tirol G, Bass C, Corniello CM, Watson G, Sanchez I, “ Castable edible pharmaceutical films”, Drug Del Tec. 2008; 8(6):35-41.
64. Cilurzo F, Cupone I, Minghetti P, Selmin F, Montanari L, “ Fast dissolving films made of maltodextrins”, Eur J Pharm Biopharm. 2008; 70(3):895-900.
65. Hideaki O, Eiji S, Yusaku S, Kaisuke Y, Yasunari T. Development of an easily swallowed film formulation. Journal of Pharmaceutics. 2008; 355:62–66.
66. Dinge A, Nagarsenker M. Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity. AAPS Pharm Sci Tech. 2008; 9(2): 349-356.
67. Ali S, Quadir A. High molecular weight povidone based films for fast dissolving drug delivery applications. Drug Del Tech. 2007; 7(6):36-43.
68. Gohel MC, Sharma Renuka, Parikh RK., Soniwala MM. Development of taste masked film of valdecoxib for oral use. Indian J Pharm Sci. 2007; 69(2):320-323.
69. Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Dev Ind Pharm. 2005; 1: 25-34.
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How to Cite
Jain, A., Ahirwar, H., Tayal, S., & Mohanty, P. (2018). FAST DISSOLVING ORAL FILMS: A TABULAR UPDATE. Journal of Drug Delivery and Therapeutics, 8(4), 10-19.