AN UPDATED REVIEW ON MODIFIED RELEASE TABLETS

  • Gaurav Gujral Research Schloar, Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India
  • Devesh Kapoor Dr. Dayaram Patel Pharmacy College, Sardarbaug, Station Road, Bardoli, Dist – Surat, Gujarat, India, Pin-394601
  • Manish Jaimini Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

Abstract

For some time now modified drug release has been studied and used extensively during the development of pharmaceutical drug products because of its advantages over immediate release formulations. As per the forecasting by Global Business Intelligence (GBI) research, the growth in oral drug delivery market will uplift in the coming years. Modified release drug products allow at least a two-fold reduction in dosing when compared to a drug that is presented in a conventional immediate release form. Modified release drug products are designed to release active pharmaceutical ingredient over a longer duration of time; At least, longer than an immediate release (I.R) formulation. Many Pharmaceutical companies also utilize the proprietary advantages of Modified release formulations to extend the patent life cycle of commercial products thereby bringing in new business.

Keywords: Immediate release (I.R), Modified release (M.R), Novel drug delivery systems (NDDS), Loading doze (LD), Maintenance doze (MD), New Drug Application (NDA)

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Author Biographies

Gaurav Gujral, Research Schloar, Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

Research Schloar, Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

Devesh Kapoor, Dr. Dayaram Patel Pharmacy College, Sardarbaug, Station Road, Bardoli, Dist – Surat, Gujarat, India, Pin-394601

Dr. Dayaram Patel Pharmacy College, Sardarbaug, Station Road, Bardoli, Dist – Surat, Gujarat, India, Pin-394601

Manish Jaimini, Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

Department of Pharmacy, Maharishi Arvind University, Jaipur, Rajasthan, India

References

1. Prescott LF, Nimmo WS, Novel drug delivery and its therapeutic application, Wiley, 1989.
2. R. Patel, J. Patel, Novel technologies of oral controlled release drug delivery system, Systematic Reviews in Pharmacy, 2010; 1:128.
3. Narasimharao R, Anusha Reddy M, Swetha Reddy N, Divyasagar P and Keerthana K. Design and Evaluation of Metformin Hydrochloride Extended Release Tablets by Direct Compression. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2011; 2(3):1118-33.
4. Grass, G. M. and Robinson, J. R. Sustained and Controlled release drug delivery systems. In Modern Pharmaceutics. Vol.196 40; 2nd ed., Banker, G.S; Rhodes, C.T; Eds; Marcel Dekker Inc: New York, 1990: 635-638.
5. Lee, V. H. L. Oral Drug Delivery. In Drug Delivery and Targeting. Hillery, A. M; Llyod, A.W; Swarbrick, J; Eds. Taylor and Francis: London and New York, 2001:165- 168.
6. Jain NK, Controlled and novel drug delivery, 1sted. New Delhi: CBS Publishers; 1997: 1-2.
7. Orange book: approved drug products with therapeutic equivalence evaluations; available online:http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm
8. Harnish patel, Dhrupesh R. Panchal, Upendra Patel, Tushar Brahmbhatt, Mayur Suthar. Matrix Type Drug Delivery System:A Review. Journal of Pharmaceutical Science and BioscientificResearch. 2011; 1(3):143-51.
9. Manish Shivadas Wani, M.H.Dehghan, et al., Controlled Released System - A Review, 2008; 6(1), 197 http://www.pharmainfo.net/reviews/controlled-releasedsystem-review, accessed on 11-09-2010.
10. Turner S, C Federici, M Hite, R Fassihi. Formulation, development and human in vitro-in vivo correlation for a novel, monolithic controlled release matrix system of high load and highly water-soluble drug niacin. Drug Development and Industrial Pharmacy. 2004; 30:797-807.
11. Sunil Kamboj, G.D.Gupta, jagmohan oberoy. “Matrix Tablets: An Important Tool for Oral Controlled-Release Dosage Forms”. Latest Reviews, 2009; 7(6), available online:http://www.pharmainfo.net/reviews/matrix-tablets-importanttool-oral-controlled-release-dosage-forms, accessed on 4-08-2009.
12. S. Kamel, N. Ali, K. Jahangir, S. M. Shah, A. A. El-Gendy.Pharmaceutical significance of cellulose: A review. EXPRESS Polymer Letters. 2008; 2(11):758–78.
13. Veeran Gowda Kadajji and Guru V. Betageri. Water Soluble Polymers for Pharmaceutical Applications. Polymers. 3; 2011:1972-2009
14. Ikoni J Ogaji, Elijah I Nep and Jennifer D Audu-Peter. Advances in Natural Polymers as Pharmaceutical Excipients. Pharmaceutica Analytica Acta. 2011; 3(1):1-16.198
15. “Challenges and Opportunities in Establishing Scientific and Regulatory Standards for Assuring Therapeutic Equivalence of Modified Release Products: Workshop Summary Report.” AAPS Journal, Vol 12. No.3
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How to Cite
Gujral, G., Kapoor, D., & Jaimini, M. (2018). AN UPDATED REVIEW ON MODIFIED RELEASE TABLETS. Journal of Drug Delivery and Therapeutics, 8(4), 5-9. https://doi.org/10.22270/jddt.v8i4.1722