A REVIEW ON CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY

  • Govind Raj Pal Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India
  • Rajeshwar Kamal Kant Arya Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India
  • Tanuj Joshi Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India
  • Dheeraj Bisht Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Abstract

In pharmaceutical industry there are some possibilities of contamination and cross-contamination because of improper cleaning of equipment, apparatus, processing area or the starting material, this can lead to severe hazards, therefore in pharmaceutical industry we can’t afford any contamination as well as cross contamination. This can be minimized by proper cleaning of equipment, apparatus as well as the processing area. TheIndustry wants to achieve these main goals with the help of GMP. This review focused on the different types of cleaning process adapted by pharmaceutical industry, how the process of cleaning validation is done. In the cleaning validation different critical parameter, factor, material and critical process are monitored and validated so that the cleaning consistency can be achieved and documented accordingly.

Keywords: Cleaning validation, contamination, clean in place, clean out of place, swab sampling, worst case

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Author Biographies

Govind Raj Pal, Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Rajeshwar Kamal Kant Arya, Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Tanuj Joshi, Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Dheeraj Bisht, Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

Department of pharmaceutical sciences Kumaun University campus Bhimtal Nainital, India

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How to Cite
1.
Raj Pal G, Arya R, Joshi T, Bisht D. A REVIEW ON CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY. JDDT [Internet]. 14May2018 [cited 1Dec.2021];8(3):138-46. Available from: http://jddtonline.info/index.php/jddt/article/view/1695