Evaluation of Antidiarrheal Activity of Methanolic Extract of Daemia extensa R. Br. Seeds

  • Praveen Sharma IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012
  • Sachin Kumar Jain IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012
  • Neelam Balekar IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

Abstract

Diarrhea is one of the most general causes for thousands of deaths each year. Consequently, identification of new source of antidiarrheal drugs becomes one of the most prominent focuses in modern research. Our aim was to investigate the antidiarrheal activity of methanolic extract of Daemia extensa R. Br. (MEDE) leaves in rats. Antidiarrheal effect was evaluated by using castor oil-induced diarrhea at 200 mg/kg and 400 mg/kg body weight in rats where the extract showed considerable antidiarrheal effect by inhibiting 49.47% and 62.85% of diarrheal period at the doses of 200 and 400mg/kg, correspondingly These observed effects are comparable to that of standard drug loperamide (5mg/kg). So these results indicate that bioactive compounds are present in methanolic extract of Daemia extensa leaves including significant anti-diarrheal activity and could be accounted for pharmacological effects.

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Author Biographies

Praveen Sharma, IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

Sachin Kumar Jain, IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

Neelam Balekar, IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

IPS Academy College of Pharmacy, Rajendra Nagar, AB Road, Indore, MP, India, 452012

References

1. Andrade SFD, Lemos M, Comunello E, Noldin VF, Filho VC ,Niero R, Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. J Ethnopharmacol,2007, 113,252-257.
2. Begum N, Mayuren C, Balaji N, Chinnapa RY,Aravind K Adv Pharmacol Toxicol,2008, 9,33-36.
3. Malairajan P, Gopala Krishnan G, Narasimhan S & Jessika-laveni K, Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals,Indian J Pharmacol ,2008,40:126-128.
4. Boyd WA, Text Book of Pathology Structure and Function in Disease. United Kingdom,1978, Lea & Febiger.
5. Jude EO & Paul A ,J Pharm Sci, 2009,22,384-390.
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How to Cite
Sharma, P., Jain, S., & Balekar, N. (2017). Evaluation of Antidiarrheal Activity of Methanolic Extract of Daemia extensa R. Br. Seeds. Journal of Drug Delivery and Therapeutics, 7(7), 229-231. https://doi.org/10.22270/jddt.v7i7.1647