COMPARATIVE STUDY OF PHENYTOIN SODIUM AND ETHANOLIC EXTRACT OF NARDOSTACHYS JATAMANSI AUGMENTED WITH PHENYTOIN SODIUM TO EVALUATE ANTI-EPILEPTIC ACTIVITY OF THE DRUG

  • Shabnam Mansuri Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India
  • Thomson Alex Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India
  • Shaily Chaudhary Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Abstract

Epilepsy is a disorder of nervous system which leads to episodes of sensory interruption, loss of perception, or seizures, coupled with irregular electrical bustle in the brain. It is generally treated by drug therapy using anti-epileptic drugs. The core objective of this study is to comparatively study anti-epileptic activity of phenytoin sodium and ethanolic extract of jatamansi augmented with phenytoin sodium. Convulsions were induced in the mice by pentylenetetrazol (PTZ) seizure model and maximal electroshock seizure (mes) model. Jatamansi extract augmented with phenytoin sodium was the drug used for the comparative study the anti-epileptic activity of phenytoin sodium. And jatamansi extract augmented with phenytoin sodium gave better results.

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Author Biographies

Shabnam Mansuri, Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Thomson Alex, Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Shaily Chaudhary, Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

Smriti College of Pharmaceutical Education, Indore (Madhya Pradesh), India

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How to Cite
Mansuri, S., Alex, T., & Chaudhary, S. (2017). COMPARATIVE STUDY OF PHENYTOIN SODIUM AND ETHANOLIC EXTRACT OF NARDOSTACHYS JATAMANSI AUGMENTED WITH PHENYTOIN SODIUM TO EVALUATE ANTI-EPILEPTIC ACTIVITY OF THE DRUG. Journal of Drug Delivery and Therapeutics, 7(7), 218-219. https://doi.org/10.22270/jddt.v7i7.1643