DESIGN, SYNTHESIS AND DOCKING STUDY OF PYRIDINE DERIVATIVE FOR ANTIDEPRESSANT ACTIVITY
On the basis of literature survey compound 2-(1H-benzo[d]imidazole-1-yl)-N-(3-cyano-4,6-diphenylpyridin-2-yl) acetamide (6) was designed. Compound 6 and imipramine were virtually studied for their antidepressant activity by performing docking studies using Molegro Virtual Docker (MVD-2013, 6.0) on human MAO (PDB ID: 2BXS). Docking studies revealed its potential antidepressant effect as compared with imipramine. The result of docking study was validated by synthesizing and screening the compound for itâ€™s in vivo antidepressant activity following forced swim test and locomotor activity using actophotometer. Finally, we conclude that the docking result and experimental results are in good agreement.
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