DESIGN, SYNTHESIS AND DOCKING STUDY OF PYRIDINE DERIVATIVE FOR ANTIDEPRESSANT ACTIVITY

  • Mitali M Naik Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India
  • Mangirish N Deshpande Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India
  • Risa Borges Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India
  • Bheemangouda S Biradar Department of Pharmacology, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa.
  • Sunil G Shingade Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Abstract

On the basis of literature survey compound 2-(1H-benzo[d]imidazole-1-yl)-N-(3-cyano-4,6-diphenylpyridin-2-yl) acetamide (6) was designed. Compound 6 and imipramine were virtually studied for their antidepressant activity by performing docking studies using Molegro Virtual Docker (MVD-2013, 6.0) on human MAO (PDB ID: 2BXS). Docking studies revealed its potential antidepressant effect as compared with imipramine. The result of docking study was validated by synthesizing and screening the compound for it’s in vivo antidepressant activity following forced swim test and locomotor activity using actophotometer. Finally, we conclude that the docking result and experimental results are in good agreement.

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Author Biographies

Mitali M Naik, Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Mangirish N Deshpande, Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Risa Borges, Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Bheemangouda S Biradar, Department of Pharmacology, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa.

Department of Pharmacology, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa.

Sunil G Shingade, Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa, India

References

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[2] Brunton LL, Lazo JS and Parker LK (2006) Goodman and Gilman’s The Pharmacological Basis of Therapeutics. Mcgraw Hill USA: 429-455.
[3] Eissa IH, El-Nagggar AM and El-Hashash MA (2016) Bio Med Chemistry, 67.:43-56.
[4] Dhingra D and Valecha R (2007) Ind J Exp Biol, 45(7).:610.
[5] Santosh P, Venugopal R, Nilakash AS, Kunjbiharis S and Mangala L (2011) Int J Pharm Pharm, 3 (1).:112-115.
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How to Cite
Naik, M., Deshpande, M., Borges, R., Biradar, B., & Shingade, S. (2017). DESIGN, SYNTHESIS AND DOCKING STUDY OF PYRIDINE DERIVATIVE FOR ANTIDEPRESSANT ACTIVITY. Journal of Drug Delivery and Therapeutics, 7(7), 202-205. https://doi.org/10.22270/jddt.v7i7.1636