MEMORY ENHANCING ACTIVITY OF HYDROALCOHOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES
The present study was to evaluate the effect of Terminalia catappa on cognitive functions and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The extract of Terminalia catappa was administered orally at three doses (100, 200 and 300 mg/kg) for 7 and 14 consecutive days to the respective groups of rats. Piracetam (120 mg/kg) was used as a standard nootropic agent. Learning and memory parameters were evaluated using elevated plus maze (EPM) and passive avoidance. Brain cholinesterase activity was evaluated. It was observed that Terminalia catappa at the above- mentioned doses after 7 and 14 days of administration in the respective groups significantly reversed scopolamine (1 mg/kg i.p.)- induced amnesia, as evidenced by a decrease in the transfer latency in the EPM task and step-down latency in the passive avoidance task. Terminalia catappa reduced the brain ChE activity in rats.Â
2. Vasudevan M, Parle M, Pharmacological actions of Thespesia populanea relevant to Alzheimerâ€™s disease Phytomedicine, 2006, 13, 677â€“87.
3. Vogel GH, Psychotropic and Neurotropic Activity; Drug discovery and evaluation: pharmacological assays, 3rd edition, Germany, 2007, 565 - 661.
4. Joshi A, Soni P, Vyas N, Javed KP, Memory enhancing activity of Buchanania Lanzan by scopolamine induced amnesia in rats, European Journal of Biomedical and Pharmaceutical Sciences, AEJBPS, 2017, 4, 355-361.
5. Joshi A, Soni P, Malviya S, Kharia A, Memory enhancing activity of Momordica charantia by scopolamine induced amnesia in rats, IJCAP , 2017 2, 11-18.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).