Pharmacological Assessment of Antidiabetic Potential of Hydroalcoholic Extract of Cassia fistula Linn. in Streptozotocin-induced Diabetic Rats

  • Sapna Malviya Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India
  • Narendra Vyas Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India
  • Ankur Joshi Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India
  • Anil Kharia Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India
  • Neelesh Malviya Smriti College of Pharmaceutical Education, Indore-452010 (M.P.), India

Abstract

Major public health problem “diabetes†is approaching epidemic proportions globally and increasing at alarming rate all over the world. The Medicinal plants of India plays important role in the management of diabetes as they possess potent activity against diabetes. The present study protocol is aimed to evaluate antidiabetic activities of hydroalcoholic extract of Cassia fistula pod in streptozotocin-induced diabetic rats. Diabetes was induced in the rats by single intraperitoneal administration of Streptozotocin (60 mg/kg b.wt.). C. fistula pod extract at three different doses (100, 200 and 500 mg/kg b.wt./day) were administered orally with for 30 days to diabetic rats. The results were compared with standard drug glibenclamide (5 mg/kg b.wt./day) treated rats. The results showed that streptozotocin treated diabetic control rats suffered with decrease in the body weight and glycogen content in the liver as well as significant increase in the blood glucose and glycosylated hemoglobin (HbA1c) levels as compared to normal control rats. Oral administration of C. fistula pod extract or glibenclamide to diabetic animals for 30 days increased body weight and hepatic glycogen content and significant reduction in the blood glucose and HbA1c levels and as compared to diabetic control rats. The present results and study showed that C. fistula pod possess significant antidiabetic activity.


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Author Biographies

Sapna Malviya, Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

 

Narendra Vyas, Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

 

Ankur Joshi, Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

 

Anil Kharia, Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

Modern Institute of Pharmaceutical Sciences, Indore-453111 (M.P.), India

 

Neelesh Malviya, Smriti College of Pharmaceutical Education, Indore-452010 (M.P.), India

Smriti College of Pharmaceutical Education, Indore-452010 (M.P.), India

 

References

1. Rahmani AH, Cassia fistula Linn: Potential candidate in the health management, Pharmcog. Rea., 2015; 7:217–224.
2. Malviya S, Rawat S, Phytopharmacological evaluation of Acacia nilotica Deile bark extract and its fractions for its effect on antidiabetic and antioxidant activities of glucose metabolism in alloxan induced diabetic rats, Inventi Imapact, Ethnopharmacol, 2012; 3:169-173.
3. Gandhi RG, Sasikumar P, Antidiabetic effect of Merremia emarginataBurm. F. in streptozotocin induced diabetic rats. APJTB, 2012; 2: 281–286.
4. Imran, M., Khan, M., Akhtar, R., Ahmed, S., & Rageeb, M. Antidiabetic and hypolipidemic effect of methanol extract of stereospermum colais fruit in streptozotocin induced diabetic rats. Journal of Drug Delivery and Therapeutics, 2016; 6(4): 41-47. doi:10.22270/jddt.v6i4.1272
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How to Cite
Malviya, S., Vyas, N., Joshi, A., Kharia, A., & Malviya, N. (2017). Pharmacological Assessment of Antidiabetic Potential of Hydroalcoholic Extract of Cassia fistula Linn. in Streptozotocin-induced Diabetic Rats. Journal of Drug Delivery and Therapeutics, 7(7), 168-169. https://doi.org/10.22270/jddt.v7i7.1623