De-novo Design of Some New Lead Compounds as Dipeptidyl Peptidase-IV Inhibitors

  • Piyush Ghode Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009
  • Sanmati K Jain Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009

Abstract

The use of dipeptidyl peptidase-IV (DPP-IV) inhibitors has been an established practice in the management of type-2 diabetes mellitus in recent years. The present study undertakes De-novo design protocol for the exploration of some new lead compounds which can further be optimized for their development as DPP-IV inhibitors. The e-lea3d drug design pipeline was used to “grow†the molecules inside the active site of DPP-IV and molecular docking results were used for the filtration of compounds with important binding interactions.

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Author Biographies

Piyush Ghode, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009

Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009

Sanmati K Jain, Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009

Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.) 495009

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How to Cite
Ghode, P., & Jain, S. (2017). De-novo Design of Some New Lead Compounds as Dipeptidyl Peptidase-IV Inhibitors. Journal of Drug Delivery and Therapeutics, 7(7), 165-167. https://doi.org/10.22270/jddt.v7i7.1621