DOCKING, SYNTHESIS AND EVALUATION OF NOVEL DERIVATIVES OF SUBSTITUTED CHALCONES AS ANTIHYPERGLYCEMIC AGENTS
Various substituted chalcone derivatives (4A-4E) were synthesized. The structures of these compounds were established by spectral (IR, 1H-NMR, Mass) analysis. The synthesized compounds were screened for their antihyperglycemic activity. Compound 4-C (2-(3-(4-methoxyphenyl)-1H-pyrazol-5-yl) phenol) was found to possess potent antihyperglycemic activity.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).