SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME IMIDAZOLIDINE DERIVATIVES OF ISONICOTINAMIDE

  • Rakesh Patel Indore Institute of Pharmacy, Indore (MP), India
  • Pritesh Paliwal Indore Institute of Pharmacy, Indore (MP), India
  • Anil Bhandari Goenka College of Pharmacy, Lachhmangarh, Sikar (Raj) India

Abstract

New series of N (2-alkyl/aryl-5-oxo-imidazolidine-1-yl) isonicotinamide derivatives were synthesized by the reaction of Schiff base with amino acetic acid in the presence of 1:4 dioxane. Synthesized compounds were evaluated for their Anti-bacterial activity against Staphylococcus aureus and Echerichia coli, Antifungal activity against Candida Albicans and Anti-tubercular activity against Mycobacterium tuberculosis. Synthesized compounds show significant activity against bacterial, fungal and mycobacterium strains. Their structures were established on the basis of elemental analysis, IR, 1H NMR and Mass Spectral data.

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Author Biographies

Rakesh Patel, Indore Institute of Pharmacy, Indore (MP), India
Indore Institute of Pharmacy, Indore (MP), India
Pritesh Paliwal, Indore Institute of Pharmacy, Indore (MP), India
Indore Institute of Pharmacy, Indore (MP), India
Anil Bhandari, Goenka College of Pharmacy, Lachhmangarh, Sikar (Raj) India
Goenka College of Pharmacy, Lachhmangarh, Sikar (Raj) India

References

1. Patel R, Bhandari A, Synthesis and antimicrobial screening of some. N-(4-oxo-2-alkyl/aryl-thiazolidine-3-yl) isonicotinamide derivatives, Der Pharmacia Sinica, 2016, 7, 28-33.
2. Patel R, Bhandari A, Synthesis and antimicrobial screening of some thiazolidine derivatives of isoniazid, Der Chemica Sinica, 2016, 7, 8-13.
3. Patel R, Bhandari A, Synthesis and Antimicrobial Screening of Some 4-Substituted-3-Chloro-2-Oxo-Azetidine Derivatives, Asian J Res Chem, 2014, 7, 950-953.
4. Ramuz H, 1981 U S Patent No. 4244957.
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How to Cite
Patel, R., Paliwal, P., & Bhandari, A. (2017). SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME IMIDAZOLIDINE DERIVATIVES OF ISONICOTINAMIDE. Journal of Drug Delivery and Therapeutics, 7(7), 150-153. https://doi.org/10.22270/jddt.v7i7.1617